The complexity of selection at the major primate beta-defensin locus

Colin A M Semple, Alison Maxwell, Philippe Gautier, Fiona M Kilanowski, Hayden Eastwood, Perdita E Barran, Julia R Dorin

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We have examined the evolution of the genes at the major human beta-defensin locus and the orthologous loci in a range of other primates and mouse. For the first time these data allow us to examine selective episodes in the more recent evolutionary history of this locus as well as the ancient past. We have used a combination of maximum likelihood based tests and a maximum parsimony based sliding window approach to give a detailed view of the varying modes of selection operating at this locus.
Original languageEnglish
Pages (from-to)32
JournalBMC Evolutionary Biology
Publication statusPublished - 2005


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