The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

Medicine & Life Sciences

• S 10 100%
• Ubiquitination 69%
• beta-Strand Protein Conformation 50%
• Binding Sites 49%
• RNA 44%
• Mutation 35%
• Peptides 20%
• Small Nuclear Ribonucleoproteins 15%
• Tumor Suppressor Protein p53 14%
• Bacteriophages 10%
• In Vitro Techniques 9%
• Protein Isoforms 8%
• Proteins 7%
• Ligands 7%
• Amino Acids 7%

Chemical Compounds

• Mutation 54%
• Binding Site 45%
• Point Group S10 34%
• Tumor Suppressor Protein 33%
• Peptide 24%
• Protein 17%
• Flexibility 16%
• Acid 7%