The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models

Treenut Saithong; Kevin J Painter; Andrew J Millar

doi:10.1371/journal.pone.0013867

The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models

Treenut Saithong, Kevin J Painter, Andrew J Millar

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.

Original language	English
Article number	e13867
Number of pages	11
Journal	PLoS ONE
Volume	5
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0013867
Publication status	Published - Nov 2010

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SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
BBSRC
8/01/07 → 31/12/12
Project: Research

Cite this

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The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models

Abstract

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SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

Cite this