Abstract
Mutations in the cytoplasmic linker regions of receptor histidine kinase and chemoreceptor proteins have been shown previously to significantly impair receptor functions. Here we demonstrate significant sequence similarities between these regions in numerous histidine kinases, methyl-accepting proteins, adenylyl cyclases and other prokaryotic signalling proteins. It is suggested that these 'HAMP domains' possess roles of regulating the phosphorylation or methylation of homodimeric receptors by transmitting the conformational changes in periplasmic ligand-binding domains to cytoplasmic signalling kinase and methyl-acceptor domains.
Original language | English |
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Pages (from-to) | 111-6 |
Number of pages | 6 |
Journal | FEMS Microbiology Letters |
Volume | 176 |
Issue number | 1 |
Publication status | Published - 1 Jul 1999 |
Keywords
- Adenylyl Cyclases
- Amino Acid Sequence
- Bacteria
- Genes, Bacterial
- Molecular Sequence Data
- Phosphoric Monoester Hydrolases
- Protein Kinases
- Proteins
- Receptors, Cytoplasmic and Nuclear
- Receptors, Peptide
- Sequence Alignment