The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis

John Liddle, Benjamin Beaufils, Margaret Binnie, Anne Bouillot, Alexis A Denis, Michael M Hann, Carl P Haslam, Duncan S Holmes, Jon P Hutchinson, Michael Kranz, Andrew McBride, Olivier Mirguet, Damian J Mole, Christopher G Mowat, Sandeep Pal, Paul Rowland, Lionel Trottet, Iain J Uings, Ann L Walker, Scott P Webster

Research output: Contribution to journalArticlepeer-review

Abstract

A series of potent, competitive and highly selective kynurenine monooxygenase inhibitors have been discovered via a substrate-based approach for the treatment of acute pancreatitis. The lead compound demonstrated good cellular potency and clear pharmacodynamic activity in vivo.

Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume27
Issue number9
Early online date9 Mar 2017
DOIs
Publication statusPublished - May 2017

Keywords

  • Journal Article

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