The downside of 'inappropriate messaging': new insight into the development of testicular germ cell tumours in young men?

Richard M Sharpe, Rod T Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

How invasive testicular germ cell tumours (TGCTs) develop from precursor carcinoma in situ/intratubular germ cell neoplasia unclassified (CIS/IGCNU) cells, and only after puberty, is unknown. In the current issue of The Journal of Pathology, Jørgensen and colleagues have compared the protein expression profile of CIS before and after puberty and in pre-invasive versus invasive TGCT and show that the mitosis-meiosis controller DMRT1 switches off in CIS cells postpubertally and is associated with invasiveness. They also show that CIS cells express a 'confusing' mix of pro- and anti-meiotic proteins; this may predispose CIS cells to accumulate extra chromosomal material which ultimately leads to tumourigenesis.
Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalThe Journal of Pathology
Volume229
Issue number4
DOIs
Publication statusPublished - Mar 2013

Keywords

  • meiosis
  • intratubular germ cell neoplasia unclassified (IGCNU)
  • carcinoma in situ (CIS)
  • MICE
  • DMRT1
  • CANCER
  • TESTIS
  • PATHOGENESIS
  • DIFFERENTIATION
  • CARCINOMA IN-SITU
  • RETINOIC ACID
  • invasive germ cell tumours
  • MEIOSIS

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