The drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response

Neha Agrawal, Renald Delanoue, Alessandra Mauri, Davide Basco, Matthieu Pasco, Bernard Thorens, Pierre Léopold*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Summary 

Adaptation of organisms to ever-changing nutritional environments relies on sensor tissues and systemic signals. Identification of these signals would help understand the physiological crosstalk between organs contributing to growth and metabolic homeostasis. Here we show that Eiger, the Drosophila TNF-α, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-producing cells (IPCs). In the condition of nutrient shortage, a metalloprotease of the TNF-α converting enzyme (TACE) family is active in fat body (adipose-like) cells, allowing the cleavage and release of adipose Eiger in the hemolymph. In the brain IPCs, Eiger activates its receptor Grindelwald, leading to JNK-dependent inhibition of insulin production. Therefore, we have identified a humoral connexion between the fat body and the brain insulin-producing cells relying on TNF-α that mediates adaptive response to nutrient deprivation.

Original languageEnglish
Pages (from-to)675-684
Number of pages10
JournalCell Metabolism
Volume23
Issue number4
DOIs
Publication statusPublished - 12 Apr 2016

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