The dual nature of the nucleolus

Alan Tartakoff*, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, David Tollervey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

Original languageEnglish
Pages (from-to)765-769
Number of pages5
JournalGenes and Development
Issue number13-14
Publication statusPublished - 1 Sept 2022

Keywords / Materials (for Non-textual outputs)

  • condensates
  • nucleolus
  • ribosome genesis


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