The dual nature of the nucleolus

Alan Tartakoff; Patrick DiMario; Eduard Hurt; Brian McStay; Vikram Govind Panse; David Tollervey

doi:10.1101/gad.349748.122

The dual nature of the nucleolus

Alan Tartakoff^*, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, David Tollervey

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

Original language	English
Pages (from-to)	765-769
Number of pages	5
Journal	Genes and Development
Volume	36
Issue number	13-14
DOIs	https://doi.org/10.1101/gad.349748.122
Publication status	Published - 1 Sept 2022

Keywords / Materials (for Non-textual outputs)

condensates
nucleolus
ribosome genesis

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AU - Tartakoff, Alan

AU - DiMario, Patrick

AU - Hurt, Eduard

AU - McStay, Brian

AU - Panse, Vikram Govind

AU - Tollervey, David

PY - 2022/9/1

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N2 - The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

AB - The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

KW - condensates

KW - nucleolus

KW - ribosome genesis

U2 - 10.1101/gad.349748.122

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JO - Genes and Development

JF - Genes and Development

IS - 13-14

ER -

The dual nature of the nucleolus

Abstract

Keywords / Materials (for Non-textual outputs)

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