TY - JOUR
T1 - The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development
AU - Stachura, Joanna
AU - Wachowska, Malgorzata
AU - Kilarski, Witold W.
AU - Güç, Esra
AU - Golab, Jakub
AU - Muchowicz, Angelika
PY - 2016/7/2
Y1 - 2016/7/2
N2 - Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).
AB - Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).
KW - Anti-lymphatic therapies
KW - CCR7
KW - lymphatic endothelial cells
KW - photodynamic therapy
KW - vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=84976542681&partnerID=8YFLogxK
U2 - 10.1080/2162402X.2016.1182278
DO - 10.1080/2162402X.2016.1182278
M3 - Review article
AN - SCOPUS:84976542681
SN - 2162-4011
VL - 5
JO - OncoImmunology
JF - OncoImmunology
IS - 7
M1 - e1182278
ER -