The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development

Joanna Stachura, Malgorzata Wachowska, Witold W. Kilarski, Esra Güç, Jakub Golab, Angelika Muchowicz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Lymphatic vasculature plays a crucial role in the immune response, enabling transport of dendritic cells (DCs) and antigens (Ags) into the lymph nodes. Unfortunately, the lymphatic system has also a negative role in the progression of cancer diseases, by facilitating the metastatic spread of many carcinomas to the draining lymph nodes. The lymphatics can promote antitumor immune response as well as tumor tolerance. Here, we review the role of lymphatic endothelial cells (LECs) in tumor progression and immunity and mechanism of action in the newest anti-lymphatic therapies, including photodynamic therapy (PDT).

Original languageEnglish
Article numbere1182278
JournalOncoImmunology
Volume5
Issue number7
DOIs
Publication statusPublished - 2 Jul 2016

Keywords / Materials (for Non-textual outputs)

  • Anti-lymphatic therapies
  • CCR7
  • lymphatic endothelial cells
  • photodynamic therapy
  • vascular endothelial growth factor

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