Projects per year
Abstract
Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many developmental genes in mouse embryonic stem cells and are required for early development. However, it is still unclear how they are targeted and how they function. We show that the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1. Our data support a model in which PRC1 and PRC2 reinforce each other's binding but suggest that the key functions of PRC1 lie beyond the enzymatic capabilities of RING1B.
Original language | English |
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Pages (from-to) | 1897-1902 |
Number of pages | 6 |
Journal | Genes & Development |
Volume | 29 |
Issue number | 18 |
DOIs | |
Publication status | Published - 15 Sep 2015 |
Keywords
- PRC1
- histone ubiquitination
- H3K27me3
- embryonic stem cell
- Polycomb
Fingerprint
Dive into the research topics of 'The E3 ubiquitin ligase activity of Ring1B is not essential for early mouse development'. Together they form a unique fingerprint.Projects
- 2 Finished
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CROATIA PROGRAMME
Wright, A., Adams, I., Aligianis, I., Baldock, R., Bickmore, W., Caceres, J., Dorin, J., Dunlop, M., FitzPatrick, D., Haley, C., Hastie, N., Hill, B., Jackson, I., Jackson, A., Kudla, G., Meehan, R., O'Connell, M., Overton, I., Patton, E., Taylor, M., Tenesa, A. & Van Heyningen, V.
1/04/12 → 31/07/13
Project: Research
Profiles
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Ian Adams
- Deanery of Molecular, Genetic and Population Health Sciences - Personal Chair of Germline Biology
- MRC Human Genetics Unit
Person: Academic: Research Active
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Wendy Bickmore
- Deanery of Molecular, Genetic and Population Health Sciences - Director of Human Genetics Unit
- MRC Human Genetics Unit
Person: Academic: Research Active