The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

S. Luc, T.C. Luis, H. Boukarabila, I.C. Macaulay, N. Buza-Vidas, T. Bouriez-Jones, M. Lutteropp, P.S. Woll, S.J. Loughran, A.J. Mead, T. Mizukami, S. Matsuoka, H. Ferry, S. Duarte, D. Atkinson, A. Domanski, S.E.W. Jacobsen, A. Hultquist, K. Anderson, J. BrownS. Soneji, R. Patient, M. De Bruijn, T. Enver, A. Farley, A. Sanjuan-Pla, C. Nerlov, C. Blackburn, C. Carella, I. Godin

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.
Original languageEnglish
Pages (from-to)412-419
Number of pages8
JournalNature Immunology
Issue number4
Publication statusPublished - 1 Apr 2012


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