The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men

Conor McClean, JAD McLaughlin, GA Burke, Marie Murphy, Tom Trinick, Ellie Duly, Gareth Davison

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ±7.1 ml kg–1 min–1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of 1 h moderate (60% max HR) exercise.PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides (LOOHs), Superoxide dismutase (SOD) and other biochemicalmarkers were measured. PWV increased at 1 h (6.49 ± 2.1 m s–1), 2 h (6.94 ± 2.4 m s–1), 3 h (7.25 ± 2.1 m s–1) and 4 h (7.41 ± 2.5 m s–1) respectively, in the control trial(P 0.05). LOOH levels decreased at 3 hpost ingestion in the exercise trial compared to levels at 3 h (P
Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalEuropean Journal of Applied Physiology
Volume100
Early online date24 Feb 2007
DOIs
Publication statusPublished - 2007

Keywords / Materials (for Non-textual outputs)

  • Exercise
  • Postprandial lipaemia
  • Oxidative stress
  • Vascular function
  • Lipid
  • hydroperoxides

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