THE EFFECT OF ALCOHOL ON ACID-SECRETION BY THE BOVINE GALL-BLADDER IN-VITRO

Sabah HUSSAIN, JN PLEVRIS, PC HAYES, IAD BOUCHIER, John Plevris

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine whether acid secretion by gall bladder mucosa is influenced by alcohol and whether hydrogen ion output is increased when the gall bladder is perfused with moderate concentrations of alcohol.

Methods: Fifty bovine gall bladders were studied. Twenty-five served as controls and 25 were perfused (in groups of five) with varying concentrations of alcohol (w/v): 0.05, 0.1, 0.2, 0.5 and 1.0%. Acid output was measured over 1 h and the results expressed as the mean.

Results: There was no significant difference between acid production by control gall bladders and those perfused with 0.05% alcohol (24.30+/-8.7 versus 18.95x8.41 nmol/h), but the acid output was significantly increased when the mucosa was exposed to 0.1 and 0.2% alcohol concentrations (50.28+/-10.2 and 29.34+/-9.1 nmol/h; P

Conclusion: This study shows that perfusion of bovine gall bladder mucosa in vitro with moderate concentrations of alcohol stimulates acid output. This observation is important for assessing the link between alcohol and the risk of gallstone formation.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalEuropean Journal of Gastroenterology & Hepatology
Volume7
Issue number2
Publication statusPublished - Feb 1995

Keywords

  • BOVINE GALL BLADDER
  • ACIDIFICATION
  • ALCOHOL
  • GALLSTONE

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