Abstract
Human recombinant macrophage CSF (CSF-1) was administered i.v. to mice. After four daily injections there was a dose-dependent increase in the responsiveness of bone marrow cells from the treated animals to CSF-1 in vitro. At the highest dose tested (20,000 U/day) there was a selective 10-fold increase in the circulating population of mature monocytes. CSF-1 treatment also increased the macrophage content of the liver and peritoneal cavity and caused splenomegaly. The macrophages isolated from the peritoneum of CSF-1-treated animals were larger and expressed higher levels of the macrophage-specific F4/80 Ag. These data demonstrate that CSF-1 can act as a circulating regulator of the mononuclear phagocyte system.
| Original language | English |
|---|---|
| Pages (from-to) | 3405-9 |
| Number of pages | 5 |
| Journal | The Journal of Immunology |
| Volume | 141 |
| Issue number | 10 |
| Publication status | Published - 15 Nov 1988 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Bone Marrow
- Colony-Stimulating Factors
- Erythrocyte Count
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Humans
- Leukocyte Count
- Liver
- Macrophages
- Male
- Mice
- Peritoneal Cavity
- Recombinant Proteins
- Spleen
- Thymidine