The effect of lipocortin 1 on neutrophil deformability

Ellen M Drost, W Macnee, S.F. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.
Original languageEnglish
Pages (from-to)188-90
Number of pages3
JournalMediators of Inflammation
Volume5
Issue number3
DOIs
Publication statusPublished - 1996

Fingerprint

Dive into the research topics of 'The effect of lipocortin 1 on neutrophil deformability'. Together they form a unique fingerprint.

Cite this