The effect of lipocortin 1 on neutrophil deformability

Ellen M Drost, W Macnee, S.F. Smith

Research output: Contribution to journalArticlepeer-review


Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.
Original languageEnglish
Pages (from-to)188-90
Number of pages3
JournalMediators of Inflammation
Issue number3
Publication statusPublished - 1996


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