The effect of ultraviolet (UV) A1, UVB and solar-simulated radiation on p53 activation and p21

P E Beattie, L E Finlan, N M Kernohan, G Thomson, T R Hupp, S H Ibbotson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

High-dose ultraviolet (UV) A1 therapy (doses in the order of 130 J cm(-2)) is effective for atopic dermatitis and scleroderma. UVA1 has been shown to induce a dose-dependent increase in p53 expression in keratinocytes.
Original languageEnglish
Pages (from-to)1001-8
Number of pages8
JournalBritish journal of dermatology
Volume152
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Apoptosis
  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Erythema
  • Humans
  • Middle Aged
  • Phosphorylation
  • Radiation Dosage
  • Radiation Injuries
  • Skin
  • Sunlight
  • Tumor Suppressor Protein p53
  • Ultraviolet Rays

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