The effects of deleterious mutations on evolution in non-recombining genomes

Research output: Contribution to journalArticlepeer-review

Abstract

Analyzing regions of the Drosophila, genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes progressively less effective in influencing the behaviour of neighbouring sites as the number of closely linked sites on a chromosome increases.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalTrends in Genetics
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Animals
  • Drosophila
  • Evolution, Molecular
  • Female
  • Genetic Variation
  • Genome, Insect
  • Male
  • Models, Genetic
  • Mutation
  • Recombination, Genetic
  • Reproduction

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