The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

Sherif Awad; Mary C Stephenson; Elisa Placidi; Luca Marciani; Dumitru Constantin-Teodosiu; Penny A Gowland; Robin C Spiller; Kenneth C H Fearon; Peter G Morris; Ian A Macdonald; Dileep N Lobo

doi:10.1016/j.clnu.2010.01.009

The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

Sherif Awad, Mary C Stephenson, Elisa Placidi, Luca Marciani, Dumitru Constantin-Teodosiu, Penny A Gowland, Robin C Spiller, Kenneth C H Fearon, Peter G Morris, Ian A Macdonald, Dileep N Lobo

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Preoperative fasting induces metabolic stress and leads to reduced postoperative insulin sensitivity, changes attenuated by preoperative carbohydrate loading. However, the mechanisms underlying these effects remain unknown. We investigated the dynamic changes in substrate metabolism and mononuclear cell mitochondrial function after fasting followed by refeeding with a drink [ONS (Fresenius Kabi, Germany)] designed to improve metabolic function preoperatively.

Original language	English
Pages (from-to)	538-44
Number of pages	7
Journal	Clinical Nutrition
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.clnu.2010.01.009
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Adolescent
Adult
Antioxidants
Beverages
Dietary Carbohydrates
Dietary Supplements
Eating
Electron Transport Chain Complex Proteins
Fasting
Glutamine
Glycogen
Humans
Leukocytes, Mononuclear
Lipid Metabolism
Liver
Male
Metabolome
Mitochondria
Muscle, Skeletal
Organ Size
Perioperative Care
Time Factors
Young Adult

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10.1016/j.clnu.2010.01.009

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Awad, S., Stephenson, M. C., Placidi, E., Marciani, L., Constantin-Teodosiu, D., Gowland, P. A., Spiller, R. C., Fearon, K. C. H., Morris, P. G., Macdonald, I. A., & Lobo, D. N. (2010). The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function. Clinical Nutrition, 29(4), 538-44. https://doi.org/10.1016/j.clnu.2010.01.009

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title = "The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function",

abstract = "Preoperative fasting induces metabolic stress and leads to reduced postoperative insulin sensitivity, changes attenuated by preoperative carbohydrate loading. However, the mechanisms underlying these effects remain unknown. We investigated the dynamic changes in substrate metabolism and mononuclear cell mitochondrial function after fasting followed by refeeding with a drink [ONS (Fresenius Kabi, Germany)] designed to improve metabolic function preoperatively.",

keywords = "Adolescent, Adult, Antioxidants, Beverages, Dietary Carbohydrates, Dietary Supplements, Eating, Electron Transport Chain Complex Proteins, Fasting, Glutamine, Glycogen, Humans, Leukocytes, Mononuclear, Lipid Metabolism, Liver, Male, Metabolome, Mitochondria, Muscle, Skeletal, Organ Size, Perioperative Care, Time Factors, Young Adult",

author = "Sherif Awad and Stephenson, {Mary C} and Elisa Placidi and Luca Marciani and Dumitru Constantin-Teodosiu and Gowland, {Penny A} and Spiller, {Robin C} and Fearon, {Kenneth C H} and Morris, {Peter G} and Macdonald, {Ian A} and Lobo, {Dileep N}",

year = "2010",

doi = "10.1016/j.clnu.2010.01.009",

language = "English",

volume = "29",

pages = "538--44",

journal = "Clinical Nutrition",

issn = "1532-1983",

publisher = "Churchill Livingstone",

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Awad, S, Stephenson, MC, Placidi, E, Marciani, L, Constantin-Teodosiu, D, Gowland, PA, Spiller, RC, Fearon, KCH, Morris, PG, Macdonald, IA & Lobo, DN 2010, 'The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function', Clinical Nutrition, vol. 29, no. 4, pp. 538-44. https://doi.org/10.1016/j.clnu.2010.01.009

TY - JOUR

T1 - The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

AU - Awad, Sherif

AU - Stephenson, Mary C

AU - Placidi, Elisa

AU - Marciani, Luca

AU - Constantin-Teodosiu, Dumitru

AU - Gowland, Penny A

AU - Spiller, Robin C

AU - Fearon, Kenneth C H

AU - Morris, Peter G

AU - Macdonald, Ian A

AU - Lobo, Dileep N

PY - 2010

Y1 - 2010

N2 - Preoperative fasting induces metabolic stress and leads to reduced postoperative insulin sensitivity, changes attenuated by preoperative carbohydrate loading. However, the mechanisms underlying these effects remain unknown. We investigated the dynamic changes in substrate metabolism and mononuclear cell mitochondrial function after fasting followed by refeeding with a drink [ONS (Fresenius Kabi, Germany)] designed to improve metabolic function preoperatively.

AB - Preoperative fasting induces metabolic stress and leads to reduced postoperative insulin sensitivity, changes attenuated by preoperative carbohydrate loading. However, the mechanisms underlying these effects remain unknown. We investigated the dynamic changes in substrate metabolism and mononuclear cell mitochondrial function after fasting followed by refeeding with a drink [ONS (Fresenius Kabi, Germany)] designed to improve metabolic function preoperatively.

KW - Adolescent

KW - Adult

KW - Antioxidants

KW - Beverages

KW - Dietary Carbohydrates

KW - Dietary Supplements

KW - Eating

KW - Electron Transport Chain Complex Proteins

KW - Fasting

KW - Glutamine

KW - Glycogen

KW - Humans

KW - Leukocytes, Mononuclear

KW - Lipid Metabolism

KW - Liver

KW - Male

KW - Metabolome

KW - Mitochondria

KW - Muscle, Skeletal

KW - Organ Size

KW - Perioperative Care

KW - Time Factors

KW - Young Adult

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U2 - 10.1016/j.clnu.2010.01.009

DO - 10.1016/j.clnu.2010.01.009

M3 - Article

C2 - 20138692

SN - 1532-1983

VL - 29

SP - 538

EP - 544

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 4

ER -

The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function

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Keywords / Materials (for Non-textual outputs)

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