TY - JOUR
T1 - The effects of pravastatin on hospital admission in hypercholesterolemic middle-aged men - West of Scotland Coronary Prevention Study
AU - Sheperd, James
AU - Cobbe, Stuart M.
AU - Ross, Lorimer A.
AU - McKillop, James H.
AU - Ford, Ian
AU - Packard, Christoper J.
AU - Macfarlane, Peter W.
AU - Isles, Christopher
AU - Oliver, Micheal F.
AU - Lever, Anthony F.
AU - Brown, Byron W.
AU - Ledingham, John G G
AU - Pocock, Stuart J.
AU - Rifkind, Basil M.
AU - Vallance, Barry D.
AU - Lorimer, Ross A.
AU - MsKillop, James H.
AU - Ballantyne, David
AU - Norrie, John
AU - Anderson, Liz
AU - Duncan, David
AU - Kean, Sharon
AU - Lawrence, Audrey
AU - McGrath, June
AU - Monthgomery, Vivette
AU - Percy, Melvyn
AU - Pomphrey, Elspeth
AU - Whitehouse, Andrew
AU - Cameron, Patricia
AU - Parker, Pamela
AU - Porteous, Fiona
AU - Flecher, Leslie
AU - Kilday, Christine
AU - Shoat, David
AU - Larif, Shahid
AU - Kennedy, Julie
AU - Bell, Margaret Anne
AU - Birell, Robert
AU - Mellies, Margot
AU - Meyer, Joseph
AU - Campbell, Wendy
PY - 1999/3/15
Y1 - 1999/3/15
N2 - OBJECTIVES The purpose of the study was to assess the effect of lipid reduction with pravastatin on hospital admissions in middle-aged men with hypercholesterolemia in the West of Scotland Coronary Prevention Study.BACKGROUND A prospective, randomized controlled trial was undertaken in primary care centers in the West of Scotland.METHODS A total of 6,595 participants randomized to receive pravastatin 40 mg or placebo daily were followed up for a mean of 4.9 years (range 3.5 to 6.1 years). Analysis of hospital admissions was undertaken according to the "intention to treat" principle both for cardiovascular diseases and noncardiovascular diseases (including malignant neoplasms, psychiatric diagnoses, trauma and other causes). A secondary analysis of hospitalization in patients who were greater than or equal to 75% compliant was performed.RESULTS During the trial, 2,198 (33%) of the 6,595 men were admitted to hospital on 4,333 occasions, of which 1,234 (28%) were for cardiovascular causes. Pravastatin reduced the number of subjects requiring hospital admission for cardiovascular causes by 21% (95% CI [confidence interval] 9 to 31, p = 0.0008) overall, and by 27% (95% CI 15 to 38) in compliant participants. The number of admissions per 1,000 subject-years for cardiovascular disease was reduced by 10.8 (95% CI 4 to 17.4, p = 0.0013) in all subjects, and by 15.6 (95% CI 8.3 to 23, p <0.0001) in compliant participants. Pravastatin had no significant influence on hospital admission for any noncardiovascular diagnostic category. There were 13.4 fewer admissions per 1,000 subject years for all causes in the pravastatin-treated group (95% CI -0.4 to 27.3, p = 0.076). No significant difference in duration of hospital stay was found between the pravastatin and placebo patients in any diagnostic group.CONCLUSIONS Pravastatin therapy reduced the burden of hospital admissions for cardiovascular disease, without any adverse effect on noncardiovascular hospitalization. (J Am Coll Cardiol 1999;33:909-15) (C) 1999 by the American College of Cardiology.
AB - OBJECTIVES The purpose of the study was to assess the effect of lipid reduction with pravastatin on hospital admissions in middle-aged men with hypercholesterolemia in the West of Scotland Coronary Prevention Study.BACKGROUND A prospective, randomized controlled trial was undertaken in primary care centers in the West of Scotland.METHODS A total of 6,595 participants randomized to receive pravastatin 40 mg or placebo daily were followed up for a mean of 4.9 years (range 3.5 to 6.1 years). Analysis of hospital admissions was undertaken according to the "intention to treat" principle both for cardiovascular diseases and noncardiovascular diseases (including malignant neoplasms, psychiatric diagnoses, trauma and other causes). A secondary analysis of hospitalization in patients who were greater than or equal to 75% compliant was performed.RESULTS During the trial, 2,198 (33%) of the 6,595 men were admitted to hospital on 4,333 occasions, of which 1,234 (28%) were for cardiovascular causes. Pravastatin reduced the number of subjects requiring hospital admission for cardiovascular causes by 21% (95% CI [confidence interval] 9 to 31, p = 0.0008) overall, and by 27% (95% CI 15 to 38) in compliant participants. The number of admissions per 1,000 subject-years for cardiovascular disease was reduced by 10.8 (95% CI 4 to 17.4, p = 0.0013) in all subjects, and by 15.6 (95% CI 8.3 to 23, p <0.0001) in compliant participants. Pravastatin had no significant influence on hospital admission for any noncardiovascular diagnostic category. There were 13.4 fewer admissions per 1,000 subject years for all causes in the pravastatin-treated group (95% CI -0.4 to 27.3, p = 0.076). No significant difference in duration of hospital stay was found between the pravastatin and placebo patients in any diagnostic group.CONCLUSIONS Pravastatin therapy reduced the burden of hospital admissions for cardiovascular disease, without any adverse effect on noncardiovascular hospitalization. (J Am Coll Cardiol 1999;33:909-15) (C) 1999 by the American College of Cardiology.
KW - CHOLESTEROL GALLSTONE
UR - http://www.scopus.com/inward/record.url?scp=0033558686&partnerID=8YFLogxK
U2 - 10.1016/S0735-1097(98)00657-3
DO - 10.1016/S0735-1097(98)00657-3
M3 - Article
C2 - 10091815
AN - SCOPUS:0033558686
SN - 0735-1097
VL - 33
SP - 909
EP - 915
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 4
ER -