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Abstract / Description of output
Objective
The aim of this study was to evaluate and compare both ovarian function and menstrual characteristics following uterine artery embolisation (UAE) and surgery.
Design
Subgroup of women from a randomised controlled trial.
Setting
Gynaecology and radiology units in Scotland, UK.
Population
Ninety-six women from the randomised controlled trial comparing embolisation with surgery as a treatment for fibroids (REST), which recruited 157 patients (106 UAE; 51 surgery).
Methods
Seventy-three women undergoing UAE and 23 women undergoing surgery (with ovarian conservation) had serum follicle-stimulating hormone (FSH) measurements taken on day 3 of the menstrual cycle prior to treatment, and at 6 and 12 months post-treatment. Data on menstrual cycle characteristics was also collected.
Main outcome measures
Ovarian failure, as defined by an FSH level of > 40 iu/l, and change in duration of menses and length of menstrual cycle.
Results
There was no significant difference in the rate of ovarian failure at 12 months between UAE (11%) and surgical patients (18%) (P = 0.44). This finding was not influenced by age. The mean duration of menstrual flow decreased significantly, from baseline to 12 months, by 1.7 days (SD 3.8), (95% CI 0.8-2.6). There was no statistically significant change in mean cycle length at 12 months (0.7 days [SD 4.9]; 95% CI [-0.5, 1.9]).
Conclusions
There is no evidence for UAE accelerating a deterioration in ovarian function at 1 year, when compared with surgery. UAE is associated with a decrease in the duration of menstrual flow at 1 year.
Original language | English |
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Pages (from-to) | 985-989 |
Number of pages | 5 |
Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
Volume | 117 |
Issue number | 8 |
DOIs | |
Publication status | Published - Jul 2010 |
Keywords / Materials (for Non-textual outputs)
- fibroids
- hysterectomy
- leiomyomata
- ovarian function
- uterine artery embolisation
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