Abstract / Description of output
The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomarkers. Our electrophotonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical control enables site-selective immobilization of different biomolecules on individual microrings within a sensor array. The combination of photonic and electrochemical characterization also provides additional quantitative information and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for sensing on the microscale.
Original language | English |
---|---|
Article number | 12769 |
Journal | Nature Communications |
Volume | 7 |
DOIs | |
Publication status | Published - 14 Sept 2016 |
Keywords / Materials (for Non-textual outputs)
- Biosensors
- micro-optics
- microresonators
- sensors and biosensors
Fingerprint
Dive into the research topics of 'The electro-photonic silicon biosensor'. Together they form a unique fingerprint.Profiles
-
Katherine Dunn
- School of Engineering - Senior Lecturer, Director of the Mechanical Engineering Discipline
- Centre for Engineering Biology
Person: Academic: Research Active