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Abstract / Description of output
Background: Frailty is increasingly present in patients with acute myocardial infarction. The electronic Frailty Index (eFI) is a validated method of identifying vulnerable older patients in the community from routine primary care date. Our aim was to assess the relationship between the eFI and outcomes in older patients hospitalised with acute myocardial infarction.
Study design and setting: Retrospective cohort study using the DataLoch Registry of Acute Coronary Syndromes comprising consecutive patients aged 65 years or over hospitalised with a myocardial infarction between October 2013 and March 2021.
Methods: Patients were classified as fit, mild, moderate or severely frail based on their electronic frailty score. Cox-regression analysis was used to determine the association between frailty category and all-cause mortality.
Results: In 4,670 patients (median age 77 years [71-84], 43% female), 1,865 (40%) were classified as fit, with 1,699 (36%), 798 (17%) and 308 (7%) classified as mild, moderate and severely frail respectively. In total, 1,142 patients died within 12 months of which 248 (13%) and 147 (48%) were classified as fit and severely frail respectively. After adjustment, any degree of frailty was associated with an increased risk of all-cause death with the risk greatest in the severely frail (reference = fit, adjusted hazard ratio 2.87 [95% confidence intervals 2.24 to 3.66]).
Conclusion: The eFI identified patients at high risk of death following myocardial infarction. Automatic calculation within administrative data is feasible and could provide a low-cost method of identifying vulnerable older patients on hospital presentation.
Study design and setting: Retrospective cohort study using the DataLoch Registry of Acute Coronary Syndromes comprising consecutive patients aged 65 years or over hospitalised with a myocardial infarction between October 2013 and March 2021.
Methods: Patients were classified as fit, mild, moderate or severely frail based on their electronic frailty score. Cox-regression analysis was used to determine the association between frailty category and all-cause mortality.
Results: In 4,670 patients (median age 77 years [71-84], 43% female), 1,865 (40%) were classified as fit, with 1,699 (36%), 798 (17%) and 308 (7%) classified as mild, moderate and severely frail respectively. In total, 1,142 patients died within 12 months of which 248 (13%) and 147 (48%) were classified as fit and severely frail respectively. After adjustment, any degree of frailty was associated with an increased risk of all-cause death with the risk greatest in the severely frail (reference = fit, adjusted hazard ratio 2.87 [95% confidence intervals 2.24 to 3.66]).
Conclusion: The eFI identified patients at high risk of death following myocardial infarction. Automatic calculation within administrative data is feasible and could provide a low-cost method of identifying vulnerable older patients on hospital presentation.
| Original language | English |
|---|---|
| Journal | Age and Ageing |
| Volume | 53 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 16 Jul 2024 |
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High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome
Mills, N., Anand, A., Chapman, A., Ferry, A., Newby, D., Strachan, F. & Tsanas, T.
1/06/20 → 31/05/25
Project: Research
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Personalised care for older patients with myocardial infarction (MiRisk)
Mills, N., Anand, A. & Lowry, M.
1/08/21 → 31/07/23
Project: Research
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