TY - JOUR
T1 - The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia
AU - Ramma, Wenda
AU - Buhimschi, Irina A
AU - Zhao, Guomao
AU - Dulay, Antonette T
AU - Nayeri, Unzila Ali
AU - Buhimschi, Catalin S
AU - Ahmed, Asif
PY - 2012
Y1 - 2012
N2 - BACKGROUND: Severe preeclampsia is associated with increased neutrophil activation and elevated serum soluble endoglin (sEng) and soluble Flt-1 (sFlt-1) in the maternal circulation. To dissect the contribution of systemic inflammation and anti-angiogenic factors in preeclampsia, we investigated the relationships between the circulating markers of neutrophil activation and anti-angiogenic factors in severe preeclampsia or systemic inflammatory state during pregnancy. METHODS AND RESULTS: Serum sEng, sFlt-1, placenta growth factor, interleukin-6 (IL-6), calprotectin, and plasma α-defensins concentrations were measured by ELISA in 88 women of similar gestational age stratified as: severe preeclampsia (sPE, n = 45), maternal systemic inflammatory response (SIR, n = 16) secondary to chorioamnionitis, pyelonephritis or appendicitis; and normotensive controls (CRL, n = 27). Neutrophil activation occurred in sPE and SIR, as α-defensins and calprotectin concentrations were two-fold higher in both groups compared to CRL (P
AB - BACKGROUND: Severe preeclampsia is associated with increased neutrophil activation and elevated serum soluble endoglin (sEng) and soluble Flt-1 (sFlt-1) in the maternal circulation. To dissect the contribution of systemic inflammation and anti-angiogenic factors in preeclampsia, we investigated the relationships between the circulating markers of neutrophil activation and anti-angiogenic factors in severe preeclampsia or systemic inflammatory state during pregnancy. METHODS AND RESULTS: Serum sEng, sFlt-1, placenta growth factor, interleukin-6 (IL-6), calprotectin, and plasma α-defensins concentrations were measured by ELISA in 88 women of similar gestational age stratified as: severe preeclampsia (sPE, n = 45), maternal systemic inflammatory response (SIR, n = 16) secondary to chorioamnionitis, pyelonephritis or appendicitis; and normotensive controls (CRL, n = 27). Neutrophil activation occurred in sPE and SIR, as α-defensins and calprotectin concentrations were two-fold higher in both groups compared to CRL (P
UR - http://www.scopus.com/inward/record.url?scp=84865135547&partnerID=8YFLogxK
U2 - 10.1007/s10456-012-9261-5
DO - 10.1007/s10456-012-9261-5
M3 - Article
C2 - 22398973
SN - 1573-7209
JO - Angiogenesis
JF - Angiogenesis
ER -