The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia

Wenda Ramma, Irina A Buhimschi, Guomao Zhao, Antonette T Dulay, Unzila Ali Nayeri, Catalin S Buhimschi, Asif Ahmed

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Severe preeclampsia is associated with increased neutrophil activation and elevated serum soluble endoglin (sEng) and soluble Flt-1 (sFlt-1) in the maternal circulation. To dissect the contribution of systemic inflammation and anti-angiogenic factors in preeclampsia, we investigated the relationships between the circulating markers of neutrophil activation and anti-angiogenic factors in severe preeclampsia or systemic inflammatory state during pregnancy. METHODS AND RESULTS: Serum sEng, sFlt-1, placenta growth factor, interleukin-6 (IL-6), calprotectin, and plasma α-defensins concentrations were measured by ELISA in 88 women of similar gestational age stratified as: severe preeclampsia (sPE, n = 45), maternal systemic inflammatory response (SIR, n = 16) secondary to chorioamnionitis, pyelonephritis or appendicitis; and normotensive controls (CRL, n = 27). Neutrophil activation occurred in sPE and SIR, as α-defensins and calprotectin concentrations were two-fold higher in both groups compared to CRL (P 
Original languageEnglish
JournalAngiogenesis
DOIs
Publication statusPublished - 2012

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