The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

H Harvala; R Gunson; P Simmonds; A Hardie; S Bennett; F Scott; H Roddie; J McKnight; T Walsh; D Rowney; A Clark; J Bremner; C Aitken; K Templeton

The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

H Harvala, R Gunson, P Simmonds, A Hardie, S Bennett, F Scott, H Roddie, J McKnight, T Walsh, D Rowney, A Clark, J Bremner, C Aitken, K Templeton

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

Original language	English
Journal	Eurosurveillance
Volume	15
Issue number	14
Publication status	Published - 2010

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Harvala, H., Gunson, R., Simmonds, P., Hardie, A., Bennett, S., Scott, F., Roddie, H., McKnight, J., Walsh, T., Rowney, D., Clark, A., Bremner, J., Aitken, C., & Templeton, K. (2010). The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009. Eurosurveillance, 15(14).

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AU - Gunson, R

AU - Simmonds, P

AU - Hardie, A

AU - Bennett, S

AU - Scott, F

AU - Roddie, H

AU - McKnight, J

AU - Walsh, T

AU - Rowney, D

AU - Clark, A

AU - Bremner, J

AU - Aitken, C

AU - Templeton, K

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AB - To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

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The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

Abstract

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