The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi, Carsten Gram Hansen, Kun-Liang Guan

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)73-9
Number of pages7
JournalNature Reviews Cancer
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2015

Keywords

  • Adaptor Proteins, Signal Transducing
  • Apoptosis
  • Cell Transformation, Neoplastic
  • Cytoskeletal Proteins
  • GTP-Binding Protein alpha Subunits
  • Humans
  • MicroRNAs
  • Neoplasms
  • Phosphoproteins
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Wnt Signaling Pathway
  • ras Proteins

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