The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi; Carsten Gram Hansen; Kun-Liang Guan

doi:10.1038/nrc3876

The emerging roles of YAP and TAZ in cancer

Toshiro Moroishi
, Carsten Gram Hansen
, Kun-Liang Guan

Research output: Contribution to journal › Literature review › peer-review

Abstract

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

Original language	English
Pages (from-to)	73-9
Number of pages	7
Journal	Nature Reviews Cancer
Volume	15
Issue number	2
DOIs	https://doi.org/10.1038/nrc3876
Publication status	Published - Feb 2015

Keywords / Materials (for Non-textual outputs)

Adaptor Proteins, Signal Transducing
Apoptosis
Cell Transformation, Neoplastic
Cytoskeletal Proteins
GTP-Binding Protein alpha Subunits
Humans
MicroRNAs
Neoplasms
Phosphoproteins
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins
Transcription Factors
Wnt Signaling Pathway
ras Proteins

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title = "The emerging roles of YAP and TAZ in cancer",

abstract = "Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.",

keywords = "Adaptor Proteins, Signal Transducing, Apoptosis, Cell Transformation, Neoplastic, Cytoskeletal Proteins, GTP-Binding Protein alpha Subunits, Humans, MicroRNAs, Neoplasms, Phosphoproteins, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Transcription Factors, Wnt Signaling Pathway, ras Proteins",

author = "Toshiro Moroishi and Hansen, \{Carsten Gram\} and Kun-Liang Guan",

year = "2015",

month = feb,

doi = "10.1038/nrc3876",

language = "English",

volume = "15",

pages = "73--9",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - The emerging roles of YAP and TAZ in cancer

AU - Moroishi, Toshiro

AU - Hansen, Carsten Gram

AU - Guan, Kun-Liang

PY - 2015/2

Y1 - 2015/2

N2 - Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

AB - Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

KW - Adaptor Proteins, Signal Transducing

KW - Apoptosis

KW - Cell Transformation, Neoplastic

KW - Cytoskeletal Proteins

KW - GTP-Binding Protein alpha Subunits

KW - Humans

KW - MicroRNAs

KW - Neoplasms

KW - Phosphoproteins

KW - Protein-Serine-Threonine Kinases

KW - Proto-Oncogene Proteins

KW - Transcription Factors

KW - Wnt Signaling Pathway

KW - ras Proteins

U2 - 10.1038/nrc3876

DO - 10.1038/nrc3876

M3 - Literature review

C2 - 25592648

SN - 1474-175X

VL - 15

SP - 73

EP - 79

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 2

ER -

The emerging roles of YAP and TAZ in cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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