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Abstract / Description of output
Methods: Participants were 248 members of the Lothian Birth Cohort 1936. At age 79 years, sedentary behaviour and physical activity was measured over 7 days using an activPAL activity monitor. Biological age was estimated using two measures of DNA methylation-based age acceleration—i.e. extrinsic and intrinsic epigenetic age acceleration. We used linear regression to assess the relationship between these two estimates of biological age and average daily time spent sedentary, number of sit-to-stand transitions, and step count.
Results: Of the six associations examined, only two were statistically significant in initial models adjusted for age and sex alone. Greater extrinsic age acceleration was associated with taking fewer steps (regression coefficient (95% CI) -0.100 (-0.008, -0.001), and greater intrinsic age acceleration was associated with making more sit-to-stand transitions (regression coefficient (95% CI) 0.006 (0.0001, 0.012). When we controlled for multiple statistical testing, neither of these associations survived correction (both p≥0.17).
Conclusion: In this cross-sectional study of 79-year-olds, we found no convincing evidence that biological age, as indexed by extrinsic or intrinsic epigenetic age acceleration, was associated with objectively measured sedentary or walking behaviour.
Keywords / Materials (for Non-textual outputs)
- Epigenetic age
- Physical activity
- Sedentary behavior
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- 5 Finished
1/05/15 → 30/04/19
1/05/14 → 31/10/17