The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease

Thomas Willnow, Corinne Antignac, Andre Brandli, Eric Christensen, Roger Cox, Duncan Davidson, Jamie Davies, Olivier Devuyst, Gregor Eichele, Nick Hastie, Andreas Schedl, Iwan Meij

Research output: Contribution to journalArticlepeer-review

Abstract

Rapid progress in genome research creates a wealth of information on the functional annotation of mammalian genome sequences. However, as we accumulate large amounts of scientific information we are facing problems of how to integrate and relate the data produced by various genomic approaches. Here, we propose the novel concept of an organ atlas where diverse data from expression maps to histological findings to mutant phenotypes can be queried, compared and visualized in the context of a three-dimensional reconstruction of the organ. We will seek proof of concept for the organ atlas by elucidating genetic pathways involved in development and pathophysiology of the kidney. Such a kidney atlas may provide a paradigm for a new systems-biology approach in functional genome research aimed at understanding the genetic bases of organ development, physiology and disease.
Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalOrganogenesis
Volume2
Issue number2
Publication statusPublished - Apr 2005

Fingerprint

Dive into the research topics of 'The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease'. Together they form a unique fingerprint.

Cite this