The Evans-Tishchenko Reaction: Scope and Applications

Kevin J Ralston; Alison N Hulme

doi:10.1055/s-0032-1316544

The Evans-Tishchenko Reaction: Scope and Applications

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

The Evans-Tishchenko reaction provides a highly diastereoselective route towards the synthesis of 1,3-anti diol monoesters, and therefore has found prominent use in a number of synthetic applications. This review summarizes recent applications of the Evans-Tishchenko reaction in natural product synthesis, and examines scope in terms of substrate range, functional group tolerance, and catalyst.

Original language	English
Article number	SS-2012-M0312-SR
Pages (from-to)	2310–2324
Number of pages	15
Journal	Synthesis: Journal of Synthetic Organic Chemistry
Volume	44
Issue number	15
Early online date	29 Jun 2012
DOIs	https://doi.org/10.1055/s-0032-1316544
Publication status	Published - Aug 2012

Keywords / Materials (for Non-textual outputs)

Evans-Tishchenko
anti 1,3-diols
diastereoselectivity
Lewis acids
samarium
natural products

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Accepted author manuscript, 2.12 MB

https://www.thieme-connect.de/ejournals/abstract/10.1055/s-0032-1316544

Cite this

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title = "The Evans-Tishchenko Reaction: Scope and Applications",

abstract = "The Evans-Tishchenko reaction provides a highly diastereoselective route towards the synthesis of 1,3-anti diol monoesters, and therefore has found prominent use in a number of synthetic applications. This review summarizes recent applications of the Evans-Tishchenko reaction in natural product synthesis, and examines scope in terms of substrate range, functional group tolerance, and catalyst.",

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AB - The Evans-Tishchenko reaction provides a highly diastereoselective route towards the synthesis of 1,3-anti diol monoesters, and therefore has found prominent use in a number of synthetic applications. This review summarizes recent applications of the Evans-Tishchenko reaction in natural product synthesis, and examines scope in terms of substrate range, functional group tolerance, and catalyst.

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KW - anti 1,3-diols

KW - diastereoselectivity

KW - Lewis acids

KW - samarium

KW - natural products

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DO - 10.1055/s-0032-1316544

M3 - Literature review

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JF - Synthesis: Journal of Synthetic Organic Chemistry

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M1 - SS-2012-M0312-SR

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The Evans-Tishchenko Reaction: Scope and Applications

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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