The Even-Handed Approach: Strategies for the Deployment of Racemic Chiral Catalysts

Louise A. Evans, Neil S. Hodnett, Guy C. Lloyd-Jones*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Asymmetric catalysis is predominantly associated with the use of enantiomerically pure chiral ligands and catalysts. Although racemic chiral catalysts have been employed quite extensively in polymerization, their utility in mainstream organic synthesis and catalyst development has arguably been rather overlooked. This Minireview collates various themes for the strategic application of racemic ligands and catalysts, ranging from the estimation of selectivity and determination of enantiomeric excess, through to control of regio- and stereochemical outcomes, and mechanistic studies. What emerges is a clear picture that, in isolation or in concert with enantiopure catalysts, the even-handed approach has much to offer.

Original languageEnglish
Pages (from-to)1526-1533
Number of pages8
JournalAngewandte Chemie International Edition
Volume51
Issue number7
DOIs
Publication statusPublished - 2012

Keywords

  • asymmetric catalysis
  • chirality
  • high-throughput screening
  • ligand design
  • synthetic methods
  • ASYMMETRIC ALLYLIC ALKYLATION
  • RING-OPENING POLYMERIZATION
  • KINETIC RESOLUTION
  • ENANTIOMERIC EXCESS
  • STEREOSELECTIVE POLYMERIZATION
  • ENANTIOSELECTIVE HYDROGENATION
  • PROPYLENE POLYMERIZATIONS
  • METALLOCENE CATALYSTS
  • POLY(LACTIC ACID)
  • SINGLE-SITE

Fingerprint

Dive into the research topics of 'The Even-Handed Approach: Strategies for the Deployment of Racemic Chiral Catalysts'. Together they form a unique fingerprint.

Cite this