The Evolution of the Use of Serum Alpha-fetoprotein in Clinical Liver Cancer Surveillance

Sarah Louise Kelly, Thomas Bird

Research output: Contribution to journalArticlepeer-review


Liver cancer is the 6th most common cancer and 2nd leading cause of cancer-related mortality. In order to improve patient survival early tumor detection is required and this necessitates accurate screening of at risk individuals. In this article we concisely review the methodologies employed for Hepatocellular Carcinoma (HCC) surveillance and how their use has evolved over the last three decades. We focus attention to serum biomarkers, particularly alphafetoprotein. We propose that by using an increasingly sophisticated approach to assess dynamic rates of change in biomarkers tailored to individual patients that screening accuracy may be improved. Additional improvements may also be possible by the incorporation of patient clinical data into such personalised screening assessments. These possibilities may hold the promise of improving cancer detection and early curative therapy for the increasing worldwide population at risk of HCC development.
Original languageEnglish
Article number1
JournalJournal of Immunobiology
Issue number4
Publication statusPublished - 31 Dec 2016


Dive into the research topics of 'The Evolution of the Use of Serum Alpha-fetoprotein in Clinical Liver Cancer Surveillance'. Together they form a unique fingerprint.

Cite this