The evolving cancer stem cell paradigm: Implications in veterinary oncology

Lisa Y. Pang*, David J. Argyle

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The existence of subpopulations of cells in cancer with increased tumour-initiating ability, self-renewal potential, and intrinsic resistance to conventional therapeutics formed the basis of the cancer stem cell model. Some tumours have since been viewed as aberrant tissues with a unidirectional hierarchical structure consisting of cancer stem cells at the apex, driving tumour growth, metastasis and relapse after therapy. Here, recent developments in cancer stem cell research are reviewed with a focus on tumour heterogeneity, cellular plasticity and cancer stem cell reprogramming. The impact of these findings on the cancer stem cell model is discussed.

Original languageEnglish
Pages (from-to)154-160
JournalVeterinary Journal
Volume205
Issue number2
Early online date31 Dec 2014
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Cancer cell plasticity
  • Cancer stem cells
  • Cellular reprogramming
  • Lineage tracing
  • Stemness
  • Tumour heterogeneity

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