Abstract / Description of output
The existence of subpopulations of cells in cancer with increased tumour-initiating ability, self-renewal potential, and intrinsic resistance to conventional therapeutics formed the basis of the cancer stem cell model. Some tumours have since been viewed as aberrant tissues with a unidirectional hierarchical structure consisting of cancer stem cells at the apex, driving tumour growth, metastasis and relapse after therapy. Here, recent developments in cancer stem cell research are reviewed with a focus on tumour heterogeneity, cellular plasticity and cancer stem cell reprogramming. The impact of these findings on the cancer stem cell model is discussed.
Original language | English |
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Pages (from-to) | 154-160 |
Journal | Veterinary Journal |
Volume | 205 |
Issue number | 2 |
Early online date | 31 Dec 2014 |
DOIs | |
Publication status | Published - 1 Jan 2015 |
Keywords / Materials (for Non-textual outputs)
- Cancer cell plasticity
- Cancer stem cells
- Cellular reprogramming
- Lineage tracing
- Stemness
- Tumour heterogeneity