The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

Alexandra D Almeida; Helen M Wise; Christopher J Hindley; Michael K Slevin; Rebecca S Hartley; Anna Philpott

doi:10.1186/1749-8104-5-1

The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

Alexandra D Almeida, Helen M Wise, Christopher J Hindley, Michael K Slevin, Rebecca S Hartley, Anna Philpott

Research output: Contribution to journal › Article › peer-review

Abstract

The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.

Original language	English
Pages (from-to)	1
Journal	Neural Development
Volume	5
DOIs	https://doi.org/10.1186/1749-8104-5-1
Publication status	Published - 2010
Externally published	Yes

Keywords

Animals
Blotting, Western
Cell Differentiation
Cell Proliferation
Cyclin E
DNA, Complementary
F-Box Proteins
Gene Expression Regulation, Developmental
In Situ Hybridization
Microinjections
Neural Crest
Plasmids
Point Mutation
Polymerase Chain Reaction
Protein Isoforms
RNA, Messenger
Sequence Deletion
Ubiquitin
Xenopus Proteins
Xenopus laevis

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10.1186/1749-8104-5-1

The F-box protein Cdc4 Fbxw7 is a novel regulator of neural crest development in Xenopus laevis
© 2010 Almeida et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.38 MBLicence: Creative Commons: Attribution (CC-BY)

http://www.neuraldevelopment.com/content/5/1/1

Cite this

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title = "The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis",

abstract = "The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.",

keywords = "Animals, Blotting, Western, Cell Differentiation, Cell Proliferation, Cyclin E, DNA, Complementary, F-Box Proteins, Gene Expression Regulation, Developmental, In Situ Hybridization, Microinjections, Neural Crest, Plasmids, Point Mutation, Polymerase Chain Reaction, Protein Isoforms, RNA, Messenger, Sequence Deletion, Ubiquitin, Xenopus Proteins, Xenopus laevis",

author = "Almeida, {Alexandra D} and Wise, {Helen M} and Hindley, {Christopher J} and Slevin, {Michael K} and Hartley, {Rebecca S} and Anna Philpott",

year = "2010",

doi = "10.1186/1749-8104-5-1",

language = "English",

volume = "5",

pages = "1",

journal = "Neural Development",

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T1 - The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

AU - Almeida, Alexandra D

AU - Wise, Helen M

AU - Hindley, Christopher J

AU - Slevin, Michael K

AU - Hartley, Rebecca S

AU - Philpott, Anna

PY - 2010

Y1 - 2010

N2 - The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.

AB - The neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.

KW - Animals

KW - Blotting, Western

KW - Cell Differentiation

KW - Cell Proliferation

KW - Cyclin E

KW - DNA, Complementary

KW - F-Box Proteins

KW - Gene Expression Regulation, Developmental

KW - In Situ Hybridization

KW - Microinjections

KW - Neural Crest

KW - Plasmids

KW - Point Mutation

KW - Polymerase Chain Reaction

KW - Protein Isoforms

KW - RNA, Messenger

KW - Sequence Deletion

KW - Ubiquitin

KW - Xenopus Proteins

KW - Xenopus laevis

U2 - 10.1186/1749-8104-5-1

DO - 10.1186/1749-8104-5-1

M3 - Article

C2 - 20047651

VL - 5

SP - 1

JO - Neural Development

JF - Neural Development

SN - 1749-8104

ER -

The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis

Abstract

Keywords

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