@article{1143116e118b4501a426018c9a674e69,
title = "The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project",
abstract = "Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context. This Perspective provides an overview of the priorities of FarmGTEx and advocates for coordinated strategies of data analysis and resource-sharing initiatives. FarmGTEx aims to serve as a platform for investigating context-specific regulatory effects, which will deepen our understanding of molecular mechanisms underlying complex phenotypes. The knowledge and insights provided by FarmGTEx will contribute to improving sustainable agriculture-based food systems, comparative biology and eventual human biomedicine.",
keywords = "Animals, Animals, Domestic/genetics, Genomics/methods, Genotype, Humans, Phenotype, Transcriptome",
author = "{FarmGTEx Consortium} and Lingzhao Fang and Jinyan Teng and Qing Lin and Zhonghao Bai and Shuli Liu and Dailu Guan and Bingjie Li and Yahui Gao and Yali Hou and Mian Gong and Zhangyuan Pan and Ying Yu and Clark, {Emily L} and Jacqueline Smith and Konrad Rawlik and Ruidong Xiang and Chamberlain, {Amanda J} and Goddard, {Michael E} and Mathew Littlejohn and Greger Larson and MacHugh, {David E} and O'Grady, {John F} and Peter S{\o}rensen and Goutam Sahana and Lund, {Mogens Sand{\o}} and Zhihua Jiang and Xiangchun Pan and Wentao Gong and Haihan Zhang and Xi He and Yuebo Zhang and Ning Gao and Jun He and Guoqiang Yi and Yuwen Liu and Zhonglin Tang and Pengju Zhao and Yang Zhou and Liangliang Fu and Xiao Wang and Dan Hao and Lei Liu and Siqian Chen and Young, {Robert S} and Xia Shen and Charley Xia and Hao Cheng and Li Ma and Cole, {John B} and Baldwin, {Ransom L} and Cong-Jun Li and {Van Tassell}, {Curtis P} and Rosen, {Benjamin D} and Nayan Bhowmik and Joan Lunney and Wansheng Liu and Leluo Guan and Xin Zhao and Ibeagha-Awemu, {Eveline M} and Yonglun Luo and Lin Lin and Oriol Canela-Xandri and Derks, {Martijn F L} and Crooijmans, {Richard P M A} and Marta G{\`o}dia and Ole Madsen and Groenen, {Martien A M} and Koltes, {James E} and Tuggle, {Christopher K} and McCarthy, {Fiona M} and Dominique Rocha and Elisabetta Giuffra and Marcel Amills and Alex Clop and Maria Ballester and Gwenola Tosser-Klopp and Jing Li and Chao Fang and Ming Fang and Qishan Wang and Zhuocheng Hou and Qin Wang and Fuping Zhao and Lin Jiang and Guiping Zhao and Zhengkui Zhou and Rong Zhou and Hehe Liu and Juan Deng and Long Jin and Mingzhou Li and Delin Mo and Xiaohong Liu and Yaosheng Chen and Xiaolong Yuan and Jiaqi Li and Shuhong Zhao and Yi Zhang and Xiangdong Ding and Dongxiao Sun and Hui-Zeng Sun and Cong Li and Yu Wang and Yu Jiang and Dongdong Wu and Wenwen Wang and Xinzhong Fan and Qin Zhang and Kui Li and Hao Zhang and Ning Yang and Xiaoxiang Hu and Wen Huang and Jiuzhou Song and Yang Wu and Jian Yang and Weiwei Wu and Claudia Kasper and Xinfeng Liu and Xiaofei Yu and Leilei Cui and Xiang Zhou and Seyoung Kim and Wei Li and Im, {Hae Kyung} and Buckler, {Edward S} and Bing Ren and Schatz, {Michael C} and Li, {Jingyi Jessica} and Palmer, {Abraham A} and Laurent Frantz and Huaijun Zhou and Zhe Zhang and Liu, {George E}",
note = "{\textcopyright} 2025. Springer Nature America, Inc.",
year = "2025",
month = apr,
doi = "10.1038/s41588-025-02121-5",
language = "English",
volume = "57",
pages = "786--796",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "4",
}