Abstract / Description of output
Because of their distinct differentiation, immunomodulatory and migratory capacities, endometrial mesenchymal stromal cells (MSCs) may provide an optimum source of therapeutic cells not only in relation to the uterus but also for regeneration of other tissues. This study reports the fate of endometrial MSCs following intrauterine application in mares. Stromal cell fractions were isolated from endometrial biopsies taken from seven reproductively healthy mares, expanded and fluorescence-labeled in culture. MSCs (15 x 106) or PBS were autologously infused into each uterine horn during early diestrus and subsequently tracked by fluorescence microscopy and flow cytometry of endometrial biopsies and blood samples taken periodically after infusion. The
Original language | English |
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Pages (from-to) | 1046-1052 |
Journal | Stem Cells and Development |
Volume | 27 |
Issue number | 15 |
Early online date | 23 May 2018 |
DOIs | |
Publication status | Published - 1 Aug 2018 |
Keywords / Materials (for Non-textual outputs)
- MSC
- Neutrophils