The fate of autologous endometrial mesenchymal stromal cells after application in the healthy equine uterus

Elisabeth Rink, Teresa Beyer, Hilari M French, Elaine Watson, Christine Aurich, Francesc Donadeu

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Because of their distinct differentiation, immunomodulatory and migratory capacities, endometrial mesenchymal stromal cells (MSCs) may provide an optimum source of therapeutic cells not only in relation to the uterus but also for regeneration of other tissues. This study reports the fate of endometrial MSCs following intrauterine application in mares. Stromal cell fractions were isolated from endometrial biopsies taken from seven reproductively healthy mares, expanded and fluorescence-labeled in culture. MSCs (15 x 106) or PBS were autologously infused into each uterine horn during early diestrus and subsequently tracked by fluorescence microscopy and flow cytometry of endometrial biopsies and blood samples taken periodically after infusion. The
Original languageEnglish
Pages (from-to)1046-1052
JournalStem Cells and Development
Volume27
Issue number15
Early online date23 May 2018
DOIs
Publication statusPublished - 1 Aug 2018

Keywords / Materials (for Non-textual outputs)

  • MSC
  • Neutrophils

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