The functional organisation of the centromere and kinetochore during meiosis

Lori B. Koch; Adele L. Marston

doi:10.1016/j.ceb.2025.102486

The functional organisation of the centromere and kinetochore during meiosis

Lori B. Koch, Adele L. Marston^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central roles in instructing this specialised chromosome segregation pattern. Accordingly, kinetochores acquire meiosis-specific modifications. Here we contextualise recent highlights in our understanding of how centromeres and kinetochores direct the sorting of chromosomes into gametes via meiosis.

Original language	English
Article number	102486
Number of pages	8
Journal	Current opinion in cell biology
Volume	94
Early online date	26 Feb 2025
DOIs	https://doi.org/10.1016/j.ceb.2025.102486
Publication status	E-pub ahead of print - 26 Feb 2025

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10.1016/j.ceb.2025.102486

1-s2.0-S0955067425000249-mainFinal published version, 593 KBLicence: CC BY

https://linkinghub.elsevier.com/retrieve/pii/S0955067425000249

The Hidden Cell Discovery Research Platform
Marston, A. (Principal Investigator), Allshire, R. (Co-investigator), Davies, O. (Co-investigator), El Karoui, M. (Co-investigator), Kustatscher, G. (Co-investigator), O'Carroll, D. (Co-investigator), Rappsilber, J. (Co-investigator) & Rosser, S. (Co-investigator)
Wellcome Trust (Rcl)
1/12/23 → 30/11/30
Project: Research
Specialization of chromosome segregation mechanisms in meiosis
Marston, A. (Principal Investigator)
Wellcome Trust (Rcl)
1/03/21 → 28/02/26
Project: Research
Molecular Origin of non-disjunction in human meiotic and early mitotic divisions
Marston, A. (Principal Investigator), Anderson, R. (Co-investigator) & Telfer, E. (Co-investigator)
Wellcome Trust (Rcl)
1/10/19 → 31/03/26
Project: Research

Cite this

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title = "The functional organisation of the centromere and kinetochore during meiosis",

abstract = "Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central roles in instructing this specialised chromosome segregation pattern. Accordingly, kinetochores acquire meiosis-specific modifications. Here we contextualise recent highlights in our understanding of how centromeres and kinetochores direct the sorting of chromosomes into gametes via meiosis.",

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AU - Koch, Lori B.

AU - Marston, Adele L.

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N2 - Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central roles in instructing this specialised chromosome segregation pattern. Accordingly, kinetochores acquire meiosis-specific modifications. Here we contextualise recent highlights in our understanding of how centromeres and kinetochores direct the sorting of chromosomes into gametes via meiosis.

AB - Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central roles in instructing this specialised chromosome segregation pattern. Accordingly, kinetochores acquire meiosis-specific modifications. Here we contextualise recent highlights in our understanding of how centromeres and kinetochores direct the sorting of chromosomes into gametes via meiosis.

U2 - 10.1016/j.ceb.2025.102486

DO - 10.1016/j.ceb.2025.102486

M3 - Review article

C2 - 40015116

SN - 0955-0674

VL - 94

JO - Current opinion in cell biology

JF - Current opinion in cell biology

M1 - 102486

ER -

The functional organisation of the centromere and kinetochore during meiosis

Abstract

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Projects

The Hidden Cell Discovery Research Platform

Specialization of chromosome segregation mechanisms in meiosis

Molecular Origin of non-disjunction in human meiotic and early mitotic divisions

Cite this