The Functions of CHIP in Age Related Disease

Kathryn Ball, Jia Ning, Erisa Nita, Catarina Dias

Research output: Contribution to journalArticlepeer-review

Abstract

CHIP is a key component of the protein homeostasis or ‘Proteostasis’ network
that maintains protein structure and function as a way to ensure the integrity of
the proteome in individual cells and the health of the whole organism. Proteostasis influences the biogenesis, folding, trafficking and degradation of proteins. Originally identified as a Hsc70 associated protein and a co-chaperone CHIP has E3-ubiquitin ligase activity and also displays an intrinsic chaperoning ability. It has become clear that CHIP is a multi-functional protein with roles in cellular processes that go beyond its co-chaperone activity. Not surprisingly, by unravelling the functions of CHIP, we are
beginning to appreciate that loss of CHIP’s integrity can lead to the development of several serious pathological conditions. Here we will describe the key features of CHIPs structure and functions with an emphasis on the non-canonical activities of CHIP before concentrating on the role it plays in protecting against the age associated pathologies of neuro degeneration and cancer.
Original languageEnglish
JournalJSM Enzymology and Protein Science
Volume1
Issue number1
Publication statusPublished - 1 Oct 2016

Keywords

  • CHIP
  • E3-LIGASE
  • Chaperone
  • Structure Function
  • Neuro degeneration
  • Cancer

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