The gene for proliferating cell nuclear antigen (Pcna) maps to mouse chromosome 2

C Abbott, A Pilz, H Moseley, J Peter

Research output: Contribution to journalArticlepeer-review

Abstract

The structural gene for proliferating cell nuclear antigen (Pcna) has been mapped to mouse Chromosome (Chr) 2 by use of a PCR-based assay. With somatic cell hybrids, Pcna was mapped between the T(2;4)13H and T(2;4)1Sn breakpoints. An interspecific backcross was employed to map Pcna 1.9 +/- 1.3 cM distal to Il-lb. This was confirmed by mapping Pcna in the BXH recombinant inbred (RI) strains; no recombinants were seen between Il-la and Pcna. In addition, a PCNA-related sequence (Pcna-rsl) was mapped to Chr 19 in the BXH RI strains.
Original languageEnglish
Pages (from-to)286-9
Number of pages4
JournalMammalian Genome
Volume3
Issue number5
Publication statusPublished - 1992

Keywords

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes
  • Cricetinae
  • Crosses, Genetic
  • Genes
  • Hybrid Cells
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Nuclear Proteins
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Proliferating Cell Nuclear Antigen

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