The genetic diversification of the HIV type 1 gag p17 gene in patients infected from a common source

P Kasper, P Simmonds, K E Schneweis, R Kaiser, B Matz, J Oldenburg, H H Brackmann, E C Holmes

Research output: Contribution to journalArticlepeer-review

Abstract

An evolutionary analysis was undertaken of HIV-1 gag p17 sequences taken from a small cohort of hemophilia B patients infected from a common batch of clotting factor concentrate. The sequence population found at seroconversion was highly homogeneous, suggesting that the infecting batch also contained little sequence variation. Genetic diversification was found in follow-up sequences taken approximately 3 years later and was generally found to be complex. Greater rates of synonymous to nonsynonymous substitution were observed, especially when comparing distantly related isolates, and the rate of synonymous substitution was used to estimate times of divergence for a number of isolates of HIV-1 including the origin of the subtypes A to H. The p17 region is therefore proposed as a useful marker for future epidemiological studies.
Original languageEnglish
Pages (from-to)1197-201
Number of pages5
JournalAids research and human retroviruses
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 1995

Keywords

  • Amino Acid Sequence
  • Base Sequence
  • Biological Evolution
  • Blood Transfusion
  • Cohort Studies
  • Follow-Up Studies
  • Gene Products, gag
  • Genetic Variation
  • HIV Antigens
  • HIV Infections
  • HIV-1
  • Hemophilia B
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Homology, Amino Acid
  • Viral Proteins
  • gag Gene Products, Human Immunodeficiency Virus

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