The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

Roz Laing; T Kikuchi; A Martinelli; I Tsai; R Beech; E Redman; R Holroyd; D Bartley; H Beasley; C Britton; D Curran; E Devaney; A Gilabert; M Hunt; S Johnston; I Kryukov; K Li; A Morrison; A Reid; Neil Sargison; G Saunders; J Wasmuth; A Wolstenholm; Matthew Berriman; John  Gilleard; James Cotton

doi:10.1186/gb-2013-14-8-r88

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

Roz Laing, T Kikuchi, A Martinelli, I Tsai, R Beech, E Redman, R Holroyd, D Bartley, H Beasley, C Britton, D Curran, E Devaney, A Gilabert, M Hunt, S Johnston, I Kryukov, K Li, A Morrison, A Reid, Neil SargisonG Saunders, J Wasmuth, A Wolstenholm, Matthew Berriman, John Gilleard, James Cotton

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans.

Original language	English
Article number	R88
Journal	Genome Biology
Volume	14
Issue number	8
DOIs	https://doi.org/10.1186/gb-2013-14-8-r88
Publication status	Published - 28 Aug 2013

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130822_Sargison_Laing-et-al_GenomeBiologyAccepted author manuscript, 425 KB
The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
© 2013 Laing et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Laing, R., Kikuchi, T., Martinelli, A., Tsai, I., Beech, R., Redman, E., Holroyd, R., Bartley, D., Beasley, H., Britton, C., Curran, D., Devaney, E., Gilabert, A., Hunt, M., Johnston, S., Kryukov, I., Li, K., Morrison, A., Reid, A., ... Cotton, J. (2013). The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biology, 14(8), Article R88. https://doi.org/10.1186/gb-2013-14-8-r88

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title = "The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery",

abstract = "The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans.",

author = "Roz Laing and T Kikuchi and A Martinelli and I Tsai and R Beech and E Redman and R Holroyd and D Bartley and H Beasley and C Britton and D Curran and E Devaney and A Gilabert and M Hunt and S Johnston and I Kryukov and K Li and A Morrison and A Reid and Neil Sargison and G Saunders and J Wasmuth and A Wolstenholm and Matthew Berriman and John Gilleard and James Cotton",

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Laing, R, Kikuchi, T, Martinelli, A, Tsai, I, Beech, R, Redman, E, Holroyd, R, Bartley, D, Beasley, H, Britton, C, Curran, D, Devaney, E, Gilabert, A, Hunt, M, Johnston, S, Kryukov, I, Li, K, Morrison, A, Reid, A, Sargison, N, Saunders, G, Wasmuth, J, Wolstenholm, A, Berriman, M, Gilleard, J & Cotton, J 2013, 'The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery', Genome Biology, vol. 14, no. 8, R88. https://doi.org/10.1186/gb-2013-14-8-r88

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T1 - The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

AU - Laing, Roz

AU - Kikuchi, T

AU - Martinelli, A

AU - Tsai, I

AU - Beech, R

AU - Redman, E

AU - Holroyd, R

AU - Bartley, D

AU - Beasley, H

AU - Britton, C

AU - Curran, D

AU - Devaney, E

AU - Gilabert, A

AU - Hunt, M

AU - Johnston, S

AU - Kryukov, I

AU - Li, K

AU - Morrison, A

AU - Reid, A

AU - Sargison, Neil

AU - Saunders, G

AU - Wasmuth, J

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AU - Berriman, Matthew

AU - Gilleard, John

AU - Cotton, James

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AB - The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans.

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DO - 10.1186/gb-2013-14-8-r88

M3 - Article

C2 - 23985316

SN - 1465-6906

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JO - Genome Biology

JF - Genome Biology

IS - 8

M1 - R88

ER -

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

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