The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Bovine Genome Sequencing & Analysis Consortium; Christine G. Elsik; Ross L. Tellam; Kim C. Worley; Richard A. Gibbs; Antonio R. R. Abatepaulo; Colette A. Abbey; David L. Adelson; Jan Aerts; Virpi Ahola; Lee Alexander; Tyler Alioto; Iassudara G. Almeida; Ariel F. Amadio; Elen Anatriello; Stylianos E. Antonarakis; Juan M. Anzola; Alex Astashyn; Suria M. Bahadue; Cynthia L. Baldwin; Wes Barris; Rebecca Baxter; Stephanie Nicole Bell; Anna K. Bennett; Gary L. Bennett; Fernando H. Biase; Clayton R. Boldt; Daniel G. Bradley; Fiona S. L. Brinkman; Candice L. Brinkmeyer-Langford; Wendy C. Brown; Michael J. Brownstein; Christian Buhay; Alexandre R. Caetano; Francisco Camara; Jeffrey A. Carroll; Wanessa A. Carvalho; Theresa Casey; Elaine P. Cervelatti; Joseph Chack; Elsa Chacko; Mimi M. Chandrabose; Jennifer E. Chapin; Charles E. Chapple; Hsiu-Chuan Chen; Lin Chen; Ye Cheng; Ze Cheng; Christopher P. Childers; Elizabeth J. Glass; Kirsty Jensen

doi:10.1126/science.1169588

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Bovine Genome Sequencing & Analysis Consortium, Christine G. Elsik, Ross L. Tellam, Kim C. Worley, Richard A. Gibbs, Antonio R. R. Abatepaulo, Colette A. Abbey, David L. Adelson, Jan Aerts, Virpi Ahola, Lee Alexander, Tyler Alioto, Iassudara G. Almeida, Ariel F. Amadio, Elen Anatriello, Stylianos E. Antonarakis, Juan M. Anzola, Alex Astashyn, Suria M. Bahadue, Cynthia L. BaldwinWes Barris, Rebecca Baxter, Stephanie Nicole Bell, Anna K. Bennett, Gary L. Bennett, Fernando H. Biase, Clayton R. Boldt, Daniel G. Bradley, Fiona S. L. Brinkman, Candice L. Brinkmeyer-Langford, Wendy C. Brown, Michael J. Brownstein, Christian Buhay, Alexandre R. Caetano, Francisco Camara, Jeffrey A. Carroll, Wanessa A. Carvalho, Theresa Casey, Elaine P. Cervelatti, Joseph Chack, Elsa Chacko, Mimi M. Chandrabose, Jennifer E. Chapin, Charles E. Chapple, Hsiu-Chuan Chen, Lin Chen, Ye Cheng, Ze Cheng, Christopher P. Childers, Elizabeth J. Glass, Kirsty Jensen

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Original language	English
Pages (from-to)	522-528
Number of pages	7
Journal	Science
Volume	324
Issue number	5926
DOIs	https://doi.org/10.1126/science.1169588
Publication status	Published - 24 Apr 2009

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10.1126/science.1169588

The Genome Sequence of Taurine Cattle A Window to Ruminant Biology and Evolution
Published in final edited form as: Science. 2009 April 24; 324(5926): 522–528. doi:10.1126/science.1169588.
Accepted author manuscript, 783 KB

http://www.sciencemag.org/content/324/5926/522

3 Finished

Quantifying the role of the MHC immune responsiveness traits in a cattle Holstein/Charolais cross population
Glass, E.
BBSRC
1/05/08 → 31/05/11
Project: Research
Toll-like receptors and dendritic cell genetic heterogeneity
Glass, E.
BBSRC
1/05/08 → 31/07/10
Project: Research
Genetics of vaccination: Studentship R Leach
Glass, E.
UK industry, commerce and public corporations
1/04/08 → 30/09/18
Project: Research

Cite this

Bovine Genome Sequencing & Analysis Consortium, Elsik, C. G., Tellam, R. L., Worley, K. C., Gibbs, R. A., Abatepaulo, A. R. R., Abbey, C. A., Adelson, D. L., Aerts, J., Ahola, V., Alexander, L., Alioto, T., Almeida, I. G., Amadio, A. F., Anatriello, E., Antonarakis, S. E., Anzola, J. M., Astashyn, A., Bahadue, S. M., ... Jensen, K. (2009). The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science, 324(5926), 522-528. https://doi.org/10.1126/science.1169588

Bovine Genome Sequencing & Analysis Consortium ; Elsik, Christine G. ; Tellam, Ross L. ; Worley, Kim C. ; Gibbs, Richard A. ; Abatepaulo, Antonio R. R. ; Abbey, Colette A. ; Adelson, David L. ; Aerts, Jan ; Ahola, Virpi ; Alexander, Lee ; Alioto, Tyler ; Almeida, Iassudara G. ; Amadio, Ariel F. ; Anatriello, Elen ; Antonarakis, Stylianos E. ; Anzola, Juan M. ; Astashyn, Alex ; Bahadue, Suria M. ; Baldwin, Cynthia L. ; Barris, Wes ; Baxter, Rebecca ; Bell, Stephanie Nicole ; Bennett, Anna K. ; Bennett, Gary L. ; Biase, Fernando H. ; Boldt, Clayton R. ; Bradley, Daniel G. ; Brinkman, Fiona S. L. ; Brinkmeyer-Langford, Candice L. ; Brown, Wendy C. ; Brownstein, Michael J. ; Buhay, Christian ; Caetano, Alexandre R. ; Camara, Francisco ; Carroll, Jeffrey A. ; Carvalho, Wanessa A. ; Casey, Theresa ; Cervelatti, Elaine P. ; Chack, Joseph ; Chacko, Elsa ; Chandrabose, Mimi M. ; Chapin, Jennifer E. ; Chapple, Charles E. ; Chen, Hsiu-Chuan ; Chen, Lin ; Cheng, Ye ; Cheng, Ze ; Childers, Christopher P. ; Glass, Elizabeth J. ; Jensen, Kirsty. / The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. In: Science. 2009 ; Vol. 324, No. 5926. pp. 522-528.

@article{c0a304b3758f47298ac582271b37a1c6,

title = "The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution",

abstract = "To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.",

author = "{Bovine Genome Sequencing & Analysis Consortium} and Elsik, {Christine G.} and Tellam, {Ross L.} and Worley, {Kim C.} and Gibbs, {Richard A.} and Abatepaulo, {Antonio R. R.} and Abbey, {Colette A.} and Adelson, {David L.} and Jan Aerts and Virpi Ahola and Lee Alexander and Tyler Alioto and Almeida, {Iassudara G.} and Amadio, {Ariel F.} and Elen Anatriello and Antonarakis, {Stylianos E.} and Anzola, {Juan M.} and Alex Astashyn and Bahadue, {Suria M.} and Baldwin, {Cynthia L.} and Wes Barris and Rebecca Baxter and Bell, {Stephanie Nicole} and Bennett, {Anna K.} and Bennett, {Gary L.} and Biase, {Fernando H.} and Boldt, {Clayton R.} and Bradley, {Daniel G.} and Brinkman, {Fiona S. L.} and Brinkmeyer-Langford, {Candice L.} and Brown, {Wendy C.} and Brownstein, {Michael J.} and Christian Buhay and Caetano, {Alexandre R.} and Francisco Camara and Carroll, {Jeffrey A.} and Carvalho, {Wanessa A.} and Theresa Casey and Cervelatti, {Elaine P.} and Joseph Chack and Elsa Chacko and Chandrabose, {Mimi M.} and Chapin, {Jennifer E.} and Chapple, {Charles E.} and Hsiu-Chuan Chen and Lin Chen and Ye Cheng and Ze Cheng and Childers, {Christopher P.} and Glass, {Elizabeth J.} and Kirsty Jensen",

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language = "English",

volume = "324",

pages = "522--528",

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Bovine Genome Sequencing & Analysis Consortium, Elsik, CG, Tellam, RL, Worley, KC, Gibbs, RA, Abatepaulo, ARR, Abbey, CA, Adelson, DL, Aerts, J, Ahola, V, Alexander, L, Alioto, T, Almeida, IG, Amadio, AF, Anatriello, E, Antonarakis, SE, Anzola, JM, Astashyn, A, Bahadue, SM, Baldwin, CL, Barris, W, Baxter, R, Bell, SN, Bennett, AK, Bennett, GL, Biase, FH, Boldt, CR, Bradley, DG, Brinkman, FSL, Brinkmeyer-Langford, CL, Brown, WC, Brownstein, MJ, Buhay, C, Caetano, AR, Camara, F, Carroll, JA, Carvalho, WA, Casey, T, Cervelatti, EP, Chack, J, Chacko, E, Chandrabose, MM, Chapin, JE, Chapple, CE, Chen, H-C, Chen, L, Cheng, Y, Cheng, Z, Childers, CP, Glass, EJ & Jensen, K 2009, 'The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution', Science, vol. 324, no. 5926, pp. 522-528. https://doi.org/10.1126/science.1169588

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. / Bovine Genome Sequencing & Analysis Consortium; Elsik, Christine G.; Tellam, Ross L.; Worley, Kim C.; Gibbs, Richard A.; Abatepaulo, Antonio R. R.; Abbey, Colette A.; Adelson, David L.; Aerts, Jan; Ahola, Virpi; Alexander, Lee; Alioto, Tyler; Almeida, Iassudara G.; Amadio, Ariel F.; Anatriello, Elen; Antonarakis, Stylianos E.; Anzola, Juan M.; Astashyn, Alex; Bahadue, Suria M.; Baldwin, Cynthia L.; Barris, Wes; Baxter, Rebecca; Bell, Stephanie Nicole; Bennett, Anna K.; Bennett, Gary L.; Biase, Fernando H.; Boldt, Clayton R.; Bradley, Daniel G.; Brinkman, Fiona S. L.; Brinkmeyer-Langford, Candice L.; Brown, Wendy C.; Brownstein, Michael J.; Buhay, Christian; Caetano, Alexandre R.; Camara, Francisco; Carroll, Jeffrey A.; Carvalho, Wanessa A.; Casey, Theresa; Cervelatti, Elaine P.; Chack, Joseph; Chacko, Elsa; Chandrabose, Mimi M.; Chapin, Jennifer E.; Chapple, Charles E.; Chen, Hsiu-Chuan; Chen, Lin; Cheng, Ye; Cheng, Ze; Childers, Christopher P.; Glass, Elizabeth J.; Jensen, Kirsty.

In: Science, Vol. 324, No. 5926, 24.04.2009, p. 522-528.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

AU - Bovine Genome Sequencing & Analysis Consortium

AU - Elsik, Christine G.

AU - Tellam, Ross L.

AU - Worley, Kim C.

AU - Gibbs, Richard A.

AU - Abatepaulo, Antonio R. R.

AU - Abbey, Colette A.

AU - Adelson, David L.

AU - Aerts, Jan

AU - Ahola, Virpi

AU - Alexander, Lee

AU - Alioto, Tyler

AU - Almeida, Iassudara G.

AU - Amadio, Ariel F.

AU - Anatriello, Elen

AU - Antonarakis, Stylianos E.

AU - Anzola, Juan M.

AU - Astashyn, Alex

AU - Bahadue, Suria M.

AU - Baldwin, Cynthia L.

AU - Barris, Wes

AU - Baxter, Rebecca

AU - Bell, Stephanie Nicole

AU - Bennett, Anna K.

AU - Bennett, Gary L.

AU - Biase, Fernando H.

AU - Boldt, Clayton R.

AU - Bradley, Daniel G.

AU - Brinkman, Fiona S. L.

AU - Brinkmeyer-Langford, Candice L.

AU - Brown, Wendy C.

AU - Brownstein, Michael J.

AU - Buhay, Christian

AU - Caetano, Alexandre R.

AU - Camara, Francisco

AU - Carroll, Jeffrey A.

AU - Carvalho, Wanessa A.

AU - Casey, Theresa

AU - Cervelatti, Elaine P.

AU - Chack, Joseph

AU - Chacko, Elsa

AU - Chandrabose, Mimi M.

AU - Chapin, Jennifer E.

AU - Chapple, Charles E.

AU - Chen, Hsiu-Chuan

AU - Chen, Lin

AU - Cheng, Ye

AU - Cheng, Ze

AU - Childers, Christopher P.

AU - Glass, Elizabeth J.

AU - Jensen, Kirsty

PY - 2009/4/24

Y1 - 2009/4/24

N2 - To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

AB - To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

U2 - 10.1126/science.1169588

DO - 10.1126/science.1169588

M3 - Article

VL - 324

SP - 522

EP - 528

JO - Science

JF - Science

SN - 0036-8075

IS - 5926

ER -

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Abstract

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Projects

Quantifying the role of the MHC immune responsiveness traits in a cattle Holstein/Charolais cross population

Toll-like receptors and dendritic cell genetic heterogeneity

Genetics of vaccination: Studentship R Leach

Cite this