The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia

R. S. Devon, S. Anderson, P. W. Teague, W. J. Muir, V. Murray, A. J. Pelosi, D. H. Blackwood, D. J. Porteous

Research output: Contribution to journalArticlepeer-review

Abstract

The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological studies in GRM subtype 5 knockout mice reveal, in one study, a sensorimotor gating deficit characteristic of schizophrenia and in another, a key role for this gene in the modulation of hippocampal NMDA-dependent synaptic plasticity. In humans, GRM5 levels are increased in certain pyramidal cell neurons in schizophrenics vs controls.(6) Finally, GRM5 has been mapped to 11q14, neighbouring a translocation that segregates with schizophrenia and related psychoses in a large Scottish family, F23 (MLOD score 6.0). We determined the intron/exon structure of GRM5 and identified a novel intragenic microsatellite. A case-control association study identified a significant difference in allele frequency distribution between schizophrenics and controls (P = 0.04). This is suggestive of involvement of the GRM5 gene in schizophrenia in this population.
Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalMolecular Psychiatry
Volume6
Issue number3
Publication statusPublished - 2001

Keywords

  • Case-Control Studies Gene Frequency Genome, Human Humans Microsatellite Repeats Molecular Sequence Data Receptors, Metabotropic Glutamate/*genetics Schizophrenia/*genetics Scotland

Fingerprint

Dive into the research topics of 'The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia'. Together they form a unique fingerprint.

Cite this