The genomics of heart failure: design and rationale of the HERMES consortium

Regeneron Genetics Center

doi:10.1002/ehf2.13517

The genomics of heart failure: design and rationale of the HERMES consortium

Regeneron Genetics Center

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.

METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model.

CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Original language	English
Journal	ESC heart failure
Early online date	3 Sept 2021
DOIs	https://doi.org/10.1002/ehf2.13517
Publication status	E-pub ahead of print - 3 Sept 2021

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10.1002/ehf2.13517Licence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

The genomics of heart failure design and rationale of the HERMES consortiumFinal published version, 652 KBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

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@article{ae80b69333af42df92687092593781be,

title = "The genomics of heart failure: design and rationale of the HERMES consortium",

abstract = "AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model.CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.",

author = "{Regeneron Genetics Center} and Lumbers, {R Thomas} and Sonia Shah and Honghuang Lin and Tomasz Czuba and Albert Henry and Swerdlow, {Daniel I} and Anders M{\"a}larstig and Charlotte Andersson and Niek Verweij and Holmes, {Michael V} and Johan {\"A}rnl{\"o}v and Per Svensson and Harry Hemingway and Neneh Sallah and Peter Almgren and Aragam, {Krishna G} and Geraldine Asselin and Backman, {Joshua D} and Biggs, {Mary L} and Bloom, {Heather L} and Eric Boersma and Jeffrey Brandimarto and {Brunner-La Rocca}, Hans-Peter and Carey, {David J} and Chaffin, {Mark D} and Chasman, {Daniel I} and Olympe Chazara and Xu Chen and Chung, {Jonathan H} and William Chutkow and Cleland, {John G F} and {de Denus}, Simon and Abbas Dehghan and Delgado, {Graciela E} and Spiros Denaxas and Doney, {Alexander S} and Marcus D{\"o}rr and Dudley, {Samuel C} and Gunnar Engstr{\"o}m and T{\~o}nu Esko and Ghazaleh Fatemifar and Felix, {Stephan B} and Chris Finan and Ian Ford and Francoise Fougerousse and Ren{\'e} Fouodjio and Mohsen Ghanbari and Sahar Ghasemi and Vilmantas Giedraitis and Franco Giulianini and Gottdiener, {John S} and Stefan Gross and Gu{\dh}bjartsson, {Dan{\'i}el F} and Hongsheng Gui and Rebecca Gutmann and Haggerty, {Christopher M} and {van der Harst}, Pim and Hedman, {{\AA}sa K} and Anna Helgadottir and Hans Hillege and Hyde, {Craig L} and Jaison Jacob and Jukema, {J Wouter} and Frederick Kamanu and Isabella Kardys and Maryam Kavousi and Kay-Tee Khaw and Kleber, {Marcus E} and Lars K{\o}ber and Andrea Koekemoer and Bill Kraus and Karoline Kuchenbaecker and Claudia Langenberg and Lars Lind and Lindgren, {Cecilia M} and Barry London and Lotta, {Luca A} and Lovering, {Ruth C} and Jian'an Luan and Patrik Magnusson and Anubha Mahajan and Douglas Mann and Margulies, {Kenneth B} and Marston, {Nicholas A} and Winfried M{\"a}rz and McMurray, {John J V} and Olle Melander and Giorgio Melloni and Mordi, {Ify R} and Morley, {Michael P} and Morris, {Andrew P} and Morrison, {Alanna C} and Nagle, {Michael W} and Nelson, {Christopher P} and Christopher Newton-Cheh and Alexander Niessner and Teemu Niiranen and Christoph Nowak and O'Donoghue, {Michelle L} and Owens, {Anjali T} and Palmer, {Colin N A} and Guillaume Par{\'e} and Markus Perola and Perreault, {Louis-Philippe Lemieux} and Eliana Portilla-Fernandez and Psaty, {Bruce M} and Rice, {Kenneth M} and Ridker, {Paul M} and Romaine, {Simon P R} and Carolina Roselli and Rotter, {Jerome I} and Ruff, {Christian T} and Sabatine, {Marc S} and Perttu Salo and Veikko Salomaa and {van Setten}, Jessica and Shalaby, {Alaa A} and Smelser, {Diane T} and Smith, {Nicholas L} and Kari Stefansson and Steen Stender and Stott, {David J} and Gar{\dh}ar Sveinbj{\"o}rnsson and Mari-Liis Tammesoo and Jean-Claude Tardif and Taylor, {Kent D} and Maris Teder-Laving and Alexander Teumer and Gu{\dh}mundur Thorgeirsson and Unnur Thorsteinsdottir and Christian Torp-Pedersen and Stella Trompet and Danny Tuckwell and Benoit Tyl and Uitterlinden, {Andre G} and Felix Vaura and Abirami Veluchamy and Uwe V{\"o}lker and Voors, {Adriaan A} and Xiaosong Wang and Wareham, {Nicholas J} and Weeke, {Peter E} and Raul Weiss and White, {Harvey D} and Wiggins, {Kerri L} and Heming Xing and Jian Yang and Yifan Yang and Yerges-Armstrong, {Laura M} and Bing Yu and Faiez Zannad and Faye Zhao and Wilk, {Jemma B} and Hilma Holm and Naveed Sattar and Lubitz, {Steven A} and Lanfear, {David E} and Svati Shah and Wells, {Quinn S} and Asselbergs, {Folkert W} and Hingorani, {Aroon D} and Marie-Pierre Dub{\'e} and Samani, {Nilesh J} and Lang, {Chim C} and Cappola, {Thomas P} and Ellinor, {Patrick T} and Vasan, {Ramachandran S} and Smith, {J Gustav}",

note = "{\textcopyright} 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",

year = "2021",

month = sep,

day = "3",

doi = "10.1002/ehf2.13517",

language = "English",

journal = "ESC heart failure",

issn = "2055-5822",

publisher = "The Heart Failure Association of the European Society of Cardiology",

}

TY - JOUR

T1 - The genomics of heart failure

T2 - design and rationale of the HERMES consortium

AU - Regeneron Genetics Center

AU - Lumbers, R Thomas

AU - Shah, Sonia

AU - Lin, Honghuang

AU - Czuba, Tomasz

AU - Henry, Albert

AU - Swerdlow, Daniel I

AU - Mälarstig, Anders

AU - Andersson, Charlotte

AU - Verweij, Niek

AU - Holmes, Michael V

AU - Ärnlöv, Johan

AU - Svensson, Per

AU - Hemingway, Harry

AU - Sallah, Neneh

AU - Almgren, Peter

AU - Aragam, Krishna G

AU - Asselin, Geraldine

AU - Backman, Joshua D

AU - Biggs, Mary L

AU - Bloom, Heather L

AU - Boersma, Eric

AU - Brandimarto, Jeffrey

AU - Brunner-La Rocca, Hans-Peter

AU - Carey, David J

AU - Chaffin, Mark D

AU - Chasman, Daniel I

AU - Chazara, Olympe

AU - Chen, Xu

AU - Chung, Jonathan H

AU - Chutkow, William

AU - Cleland, John G F

AU - de Denus, Simon

AU - Dehghan, Abbas

AU - Delgado, Graciela E

AU - Denaxas, Spiros

AU - Doney, Alexander S

AU - Dörr, Marcus

AU - Dudley, Samuel C

AU - Engström, Gunnar

AU - Esko, Tõnu

AU - Fatemifar, Ghazaleh

AU - Felix, Stephan B

AU - Finan, Chris

AU - Ford, Ian

AU - Fougerousse, Francoise

AU - Fouodjio, René

AU - Ghanbari, Mohsen

AU - Ghasemi, Sahar

AU - Giedraitis, Vilmantas

AU - Giulianini, Franco

AU - Gottdiener, John S

AU - Gross, Stefan

AU - Guðbjartsson, Daníel F

AU - Gui, Hongsheng

AU - Gutmann, Rebecca

AU - Haggerty, Christopher M

AU - van der Harst, Pim

AU - Hedman, Åsa K

AU - Helgadottir, Anna

AU - Hillege, Hans

AU - Hyde, Craig L

AU - Jacob, Jaison

AU - Jukema, J Wouter

AU - Kamanu, Frederick

AU - Kardys, Isabella

AU - Kavousi, Maryam

AU - Khaw, Kay-Tee

AU - Kleber, Marcus E

AU - Køber, Lars

AU - Koekemoer, Andrea

AU - Kraus, Bill

AU - Kuchenbaecker, Karoline

AU - Langenberg, Claudia

AU - Lind, Lars

AU - Lindgren, Cecilia M

AU - London, Barry

AU - Lotta, Luca A

AU - Lovering, Ruth C

AU - Luan, Jian'an

AU - Magnusson, Patrik

AU - Mahajan, Anubha

AU - Mann, Douglas

AU - Margulies, Kenneth B

AU - Marston, Nicholas A

AU - März, Winfried

AU - McMurray, John J V

AU - Melander, Olle

AU - Melloni, Giorgio

AU - Mordi, Ify R

AU - Morley, Michael P

AU - Morris, Andrew P

AU - Morrison, Alanna C

AU - Nagle, Michael W

AU - Nelson, Christopher P

AU - Newton-Cheh, Christopher

AU - Niessner, Alexander

AU - Niiranen, Teemu

AU - Nowak, Christoph

AU - O'Donoghue, Michelle L

AU - Owens, Anjali T

AU - Palmer, Colin N A

AU - Paré, Guillaume

AU - Perola, Markus

AU - Perreault, Louis-Philippe Lemieux

AU - Portilla-Fernandez, Eliana

AU - Psaty, Bruce M

AU - Rice, Kenneth M

AU - Ridker, Paul M

AU - Romaine, Simon P R

AU - Roselli, Carolina

AU - Rotter, Jerome I

AU - Ruff, Christian T

AU - Sabatine, Marc S

AU - Salo, Perttu

AU - Salomaa, Veikko

AU - van Setten, Jessica

AU - Shalaby, Alaa A

AU - Smelser, Diane T

AU - Smith, Nicholas L

AU - Stefansson, Kari

AU - Stender, Steen

AU - Stott, David J

AU - Sveinbjörnsson, Garðar

AU - Tammesoo, Mari-Liis

AU - Tardif, Jean-Claude

AU - Taylor, Kent D

AU - Teder-Laving, Maris

AU - Teumer, Alexander

AU - Thorgeirsson, Guðmundur

AU - Thorsteinsdottir, Unnur

AU - Torp-Pedersen, Christian

AU - Trompet, Stella

AU - Tuckwell, Danny

AU - Tyl, Benoit

AU - Uitterlinden, Andre G

AU - Vaura, Felix

AU - Veluchamy, Abirami

AU - Völker, Uwe

AU - Voors, Adriaan A

AU - Wang, Xiaosong

AU - Wareham, Nicholas J

AU - Weeke, Peter E

AU - Weiss, Raul

AU - White, Harvey D

AU - Wiggins, Kerri L

AU - Xing, Heming

AU - Yang, Jian

AU - Yang, Yifan

AU - Yerges-Armstrong, Laura M

AU - Yu, Bing

AU - Zannad, Faiez

AU - Zhao, Faye

AU - Wilk, Jemma B

AU - Holm, Hilma

AU - Sattar, Naveed

AU - Lubitz, Steven A

AU - Lanfear, David E

AU - Shah, Svati

AU - Wells, Quinn S

AU - Asselbergs, Folkert W

AU - Hingorani, Aroon D

AU - Dubé, Marie-Pierre

AU - Samani, Nilesh J

AU - Lang, Chim C

AU - Cappola, Thomas P

AU - Ellinor, Patrick T

AU - Vasan, Ramachandran S

AU - Smith, J Gustav

PY - 2021/9/3

Y1 - 2021/9/3

N2 - AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model.CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

AB - AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure.METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model.CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

U2 - 10.1002/ehf2.13517

DO - 10.1002/ehf2.13517

M3 - Article

C2 - 34480422

SN - 2055-5822

JO - ESC heart failure

JF - ESC heart failure

ER -

The genomics of heart failure: design and rationale of the HERMES consortium

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