The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models

H Fuchs; V Gailus-Durner; T Adler; J A Aguilar Pimentel; L Becker; I Bolle; M Brielmeier; J Calzada-Wack; C Dalke; N Ehrhardt; N Fasnacht; B Ferwagner; U Frischmann; W Hans; S M Hölter; G Hölzlwimmer; M Horsch; A Javaheri; M Kallnik; E Kling; C Lengger; H Maier; I Mossbrugger; C Mörth; B Naton; U Nöth; B Pasche; C Prehn; G Przemeck; O Puk; I Racz; B Rathkolb; J Rozman; K Schäble; R Schreiner; A Schrewe; C Sina; R Steinkamp; F Thiele; M Willershäuser; R Zeh; J Adamski; D H Busch; J Beckers; H Behrendt; H Daniel; I Esposito; J Favor; J Graw; G Heldmaier; H Höfler; B Ivandic; H Katus; M Klingenspor; T Klopstock; A Lengeling; M Mempel; W Müller; S Neschen; M Ollert; L Quintanilla-Martinez; P Rosenstiel; J Schmidt; S Schreiber; K Schughart; H Schulz; E Wolf; W Wurst; A Zimmer; M Hrabé de Angelis

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models

H Fuchs, V Gailus-Durner, T Adler, J A Aguilar Pimentel, L Becker, I Bolle, M Brielmeier, J Calzada-Wack, C Dalke, N Ehrhardt, N Fasnacht, B Ferwagner, U Frischmann, W Hans, S M Hölter, G Hölzlwimmer, M Horsch, A Javaheri, M Kallnik, E KlingC Lengger, H Maier, I Mossbrugger, C Mörth, B Naton, U Nöth, B Pasche, C Prehn, G Przemeck, O Puk, I Racz, B Rathkolb, J Rozman, K Schäble, R Schreiner, A Schrewe, C Sina, R Steinkamp, F Thiele, M Willershäuser, R Zeh, J Adamski, D H Busch, J Beckers, H Behrendt, H Daniel, I Esposito, J Favor, J Graw, G Heldmaier, H Höfler, B Ivandic, H Katus, M Klingenspor, T Klopstock, A Lengeling, M Mempel, W Müller, S Neschen, M Ollert, L Quintanilla-Martinez, P Rosenstiel, J Schmidt, S Schreiber, K Schughart, H Schulz, E Wolf, W Wurst, A Zimmer, M Hrabé de Angelis

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Literature review › peer-review

Abstract

The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line--a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, host-pathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.

Original language	English
Pages (from-to)	236-43
Number of pages	8
Journal	Current Pharmaceutical Biotechnology
Volume	10
Issue number	2
Publication status	Published - Feb 2009

Cite this

Fuchs, H., Gailus-Durner, V., Adler, T., Pimentel, J. A. A., Becker, L., Bolle, I., Brielmeier, M., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Fasnacht, N., Ferwagner, B., Frischmann, U., Hans, W., Hölter, S. M., Hölzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., ... Hrabé de Angelis, M. (2009). The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Current Pharmaceutical Biotechnology, 10(2), 236-43.

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title = "The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models",

abstract = "The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line--a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, host-pathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.",

author = "H Fuchs and V Gailus-Durner and T Adler and Pimentel, {J A Aguilar} and L Becker and I Bolle and M Brielmeier and J Calzada-Wack and C Dalke and N Ehrhardt and N Fasnacht and B Ferwagner and U Frischmann and W Hans and H{\"o}lter, {S M} and G H{\"o}lzlwimmer and M Horsch and A Javaheri and M Kallnik and E Kling and C Lengger and H Maier and I Mossbrugger and C M{\"o}rth and B Naton and U N{\"o}th and B Pasche and C Prehn and G Przemeck and O Puk and I Racz and B Rathkolb and J Rozman and K Sch{\"a}ble and R Schreiner and A Schrewe and C Sina and R Steinkamp and F Thiele and M Willersh{\"a}user and R Zeh and J Adamski and Busch, {D H} and J Beckers and H Behrendt and H Daniel and I Esposito and J Favor and J Graw and G Heldmaier and H H{\"o}fler and B Ivandic and H Katus and M Klingenspor and T Klopstock and A Lengeling and M Mempel and W M{\"u}ller and S Neschen and M Ollert and L Quintanilla-Martinez and P Rosenstiel and J Schmidt and S Schreiber and K Schughart and H Schulz and E Wolf and W Wurst and A Zimmer and {Hrab{\'e} de Angelis}, M",

year = "2009",

month = feb,

language = "English",

volume = "10",

pages = "236--43",

journal = "Current Pharmaceutical Biotechnology",

issn = "1389-2010",

publisher = "Bentham Science Publishers B.V.",

number = "2",

}

Fuchs, H, Gailus-Durner, V, Adler, T, Pimentel, JAA, Becker, L, Bolle, I, Brielmeier, M, Calzada-Wack, J, Dalke, C, Ehrhardt, N, Fasnacht, N, Ferwagner, B, Frischmann, U, Hans, W, Hölter, SM, Hölzlwimmer, G, Horsch, M, Javaheri, A, Kallnik, M, Kling, E, Lengger, C, Maier, H, Mossbrugger, I, Mörth, C, Naton, B, Nöth, U, Pasche, B, Prehn, C, Przemeck, G, Puk, O, Racz, I, Rathkolb, B, Rozman, J, Schäble, K, Schreiner, R, Schrewe, A, Sina, C, Steinkamp, R, Thiele, F, Willershäuser, M, Zeh, R, Adamski, J, Busch, DH, Beckers, J, Behrendt, H, Daniel, H, Esposito, I, Favor, J, Graw, J, Heldmaier, G, Höfler, H, Ivandic, B, Katus, H, Klingenspor, M, Klopstock, T, Lengeling, A, Mempel, M, Müller, W, Neschen, S, Ollert, M, Quintanilla-Martinez, L, Rosenstiel, P, Schmidt, J, Schreiber, S, Schughart, K, Schulz, H, Wolf, E, Wurst, W, Zimmer, A & Hrabé de Angelis, M 2009, 'The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models', Current Pharmaceutical Biotechnology, vol. 10, no. 2, pp. 236-43.

TY - JOUR

T1 - The German Mouse Clinic

T2 - a platform for systemic phenotype analysis of mouse models

AU - Fuchs, H

AU - Gailus-Durner, V

AU - Adler, T

AU - Pimentel, J A Aguilar

AU - Becker, L

AU - Bolle, I

AU - Brielmeier, M

AU - Calzada-Wack, J

AU - Dalke, C

AU - Ehrhardt, N

AU - Fasnacht, N

AU - Ferwagner, B

AU - Frischmann, U

AU - Hans, W

AU - Hölter, S M

AU - Hölzlwimmer, G

AU - Horsch, M

AU - Javaheri, A

AU - Kallnik, M

AU - Kling, E

AU - Lengger, C

AU - Maier, H

AU - Mossbrugger, I

AU - Mörth, C

AU - Naton, B

AU - Nöth, U

AU - Pasche, B

AU - Prehn, C

AU - Przemeck, G

AU - Puk, O

AU - Racz, I

AU - Rathkolb, B

AU - Rozman, J

AU - Schäble, K

AU - Schreiner, R

AU - Schrewe, A

AU - Sina, C

AU - Steinkamp, R

AU - Thiele, F

AU - Willershäuser, M

AU - Zeh, R

AU - Adamski, J

AU - Busch, D H

AU - Beckers, J

AU - Behrendt, H

AU - Daniel, H

AU - Esposito, I

AU - Favor, J

AU - Graw, J

AU - Heldmaier, G

AU - Höfler, H

AU - Ivandic, B

AU - Katus, H

AU - Klingenspor, M

AU - Klopstock, T

AU - Lengeling, A

AU - Mempel, M

AU - Müller, W

AU - Neschen, S

AU - Ollert, M

AU - Quintanilla-Martinez, L

AU - Rosenstiel, P

AU - Schmidt, J

AU - Schreiber, S

AU - Schughart, K

AU - Schulz, H

AU - Wolf, E

AU - Wurst, W

AU - Zimmer, A

AU - Hrabé de Angelis, M

PY - 2009/2

Y1 - 2009/2

N2 - The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line--a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, host-pathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.

AB - The German Mouse Clinic (GMC) is a large scale phenotyping center where mouse mutant lines are analyzed in a standardized and comprehensive way. The result is an almost complete picture of the phenotype of a mouse mutant line--a systemic view. At the GMC, expert scientists from various fields of mouse research work in close cooperation with clinicians side by side at one location. The phenotype screens comprise the following areas: allergy, behavior, clinical chemistry, cardiovascular analyses, dysmorphology, bone and cartilage, energy metabolism, eye and vision, host-pathogen interactions, immunology, lung function, molecular phenotyping, neurology, nociception, steroid metabolism, and pathology. The German Mouse Clinic is an open access platform that offers a collaboration-based phenotyping to the scientific community (www.mouseclinic.de). More than 80 mutant lines have been analyzed in a primary screen for 320 parameters, and for 95% of the mutant lines we have found new or additional phenotypes that were not associated with the mouse line before. Our data contributed to the association of mutant mouse lines to the corresponding human disease. In addition, the systemic phenotype analysis accounts for pleiotropic gene functions and refines previous phenotypic characterizations. This is an important basis for the analysis of underlying disease mechanisms. We are currently setting up a platform that will include environmental challenge tests to decipher genome-environmental interactions in the areas nutrition, exercise, air, stress and infection with different standardized experiments. This will help us to identify genetic predispositions as susceptibility factors for environmental influences.

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M3 - Literature review

C2 - 19199957

SN - 1389-2010

VL - 10

SP - 236

EP - 243

JO - Current Pharmaceutical Biotechnology

JF - Current Pharmaceutical Biotechnology

IS - 2

ER -

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models

Abstract

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