The global distribution and spread of the mobilized colistin resistance gene mcr-1

Ruobing Wang; Lucy van Dorp; Liam Shaw; Phelim Bradley; Qi Wang; Xiaojuan Wang; Longyang Jin; Qing Zhang; Yuqing Liu; Adrien Rieux; Thamarai Dorai-Schneiders; Lucy Weinert; Zamin Iqbal; Xavier Didelot; Hui Wang; Francois Balloux

doi:10.1038/s41467-018-03205-z

The global distribution and spread of the mobilized colistin resistance gene mcr-1

Ruobing Wang, Lucy van Dorp, Liam Shaw, Phelim Bradley, Qi Wang, Xiaojuan Wang, Longyang Jin, Qing Zhang, Yuqing Liu, Adrien Rieux, Thamarai Dorai-Schneiders, Lucy Weinert, Zamin Iqbal, Xavier Didelot, Hui Wang, Francois Balloux

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Abstract / Description of output

Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

Original language	English
Article number	1179
Number of pages	9
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-03205-z
Publication status	Published - 21 Mar 2018

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The global distribution and spread of the mobilized colistin resistance gene mcr-1
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Thamarai Dorai-Schneiders
- Thamarai.Schneidersed.acuk
- Deanery of Biomedical Sciences - Reader
- Division of Infection and Pathway Medicine
Person: Academic: Research Active (Teaching)

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title = "The global distribution and spread of the mobilized colistin resistance gene mcr-1",

abstract = "Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.",

author = "Ruobing Wang and {van Dorp}, Lucy and Liam Shaw and Phelim Bradley and Qi Wang and Xiaojuan Wang and Longyang Jin and Qing Zhang and Yuqing Liu and Adrien Rieux and Thamarai Dorai-Schneiders and Lucy Weinert and Zamin Iqbal and Xavier Didelot and Hui Wang and Francois Balloux",

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doi = "10.1038/s41467-018-03205-z",

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T1 - The global distribution and spread of the mobilized colistin resistance gene mcr-1

AU - Wang, Ruobing

AU - van Dorp, Lucy

AU - Shaw, Liam

AU - Bradley, Phelim

AU - Wang, Qi

AU - Wang, Xiaojuan

AU - Jin, Longyang

AU - Zhang, Qing

AU - Liu, Yuqing

AU - Rieux, Adrien

AU - Dorai-Schneiders, Thamarai

AU - Weinert, Lucy

AU - Iqbal, Zamin

AU - Didelot, Xavier

AU - Wang, Hui

AU - Balloux, Francois

PY - 2018/3/21

Y1 - 2018/3/21

N2 - Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

AB - Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.

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DO - 10.1038/s41467-018-03205-z

M3 - Article

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 1179

ER -

The global distribution and spread of the mobilized colistin resistance gene mcr-1

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