The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019

Jianhui Zhao; Liying Xu; Jing Sun; Mingyang Song; Lijuan Wang; Shuai Yuan; Yingshuang Zhu; Zhengwei Wan; Susanna C. Larsson; Konstantinos K Tsilidis; Malcolm G Dunlop; Harry Campbell; Igor Rudan; Peige Song; Evropi Theodoratou; Kefeng Ding; Xue Li

doi:10.1136/bmjonc-2023-000049

The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019

Jianhui Zhao, Liying Xu, Jing Sun, Mingyang Song, Lijuan Wang, Shuai Yuan, Yingshuang Zhu, Zhengwei Wan, Susanna C. Larsson, Konstantinos K Tsilidis, Malcolm G Dunlop, Harry Campbell, Igor Rudan, Peige Song, Evropi Theodoratou, Kefeng Ding^*, Xue Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVE This study aimed to explore the global burden of early-onset cancer (<50 years) based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwide.

DESIGN A survey for global burden of early-onset cancer from 1990 to 2019.

DATA SOURCE The GBD database in 2019 based on a total of 1250 censuses and 747 location-years of population registry data worldwide. Individuals with early-onset cancer between 1990 and 2019 from GBD database 2019.

MAIN OUTCOMES AND MEASURES Incidence, deaths, disability-adjusted life-years (DALYs) and risk factors for 29 early-onset cancer groups.

RESULTS Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% betwen 1990-2019. Early-onset breast, tracheal, bronchus, and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle sociodemographic index regions had the highest burden of early-onset cancer. The age-standardized incidence rate of early-onset cancer increased with the sociodemographic index, and the age-standardized death rate decreased considerably when sociodemographic index increased from 0.7 to 1. The projections indicated that the global age-standardized incidence and death rates of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in friuts, high in sodium and low in milk, etc.), alcohol consumption, and tobacco use are the main risk factors underlying early-onset cancers.

CONCLUSIONS Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex, and cancer types, which could burden countries' health systems. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.

Original language	English
Article number	e000049
Number of pages	12
Journal	BMJ Oncology
Volume	2
DOIs	https://doi.org/10.1136/bmjonc-2023-000049
Publication status	Published - 5 Sept 2023

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Colorectal cancer reduction through risk stratification of screening, follow-up and treatment
Theodoratou, E.
UK-based charities
1/05/17 → 30/04/23
Project: Research

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Zhao, J., Xu, L., Sun, J., Song, M., Wang, L., Yuan, S., Zhu, Y., Wan, Z., Larsson, S. C., Tsilidis, K. K., Dunlop, M. G., Campbell, H., Rudan, I., Song, P., Theodoratou, E., Ding, K., & Li, X. (2023). The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019. BMJ Oncology, 2, Article e000049. https://doi.org/10.1136/bmjonc-2023-000049

@article{9cbee1cc2fc44c9abc4720b7f0e66d27,

title = "The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019",

abstract = "OBJECTIVE This study aimed to explore the global burden of early-onset cancer (<50 years) based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwide.DESIGN A survey for global burden of early-onset cancer from 1990 to 2019.DATA SOURCE The GBD database in 2019 based on a total of 1250 censuses and 747 location-years of population registry data worldwide. Individuals with early-onset cancer between 1990 and 2019 from GBD database 2019. MAIN OUTCOMES AND MEASURES Incidence, deaths, disability-adjusted life-years (DALYs) and risk factors for 29 early-onset cancer groups.RESULTS Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% betwen 1990-2019. Early-onset breast, tracheal, bronchus, and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle sociodemographic index regions had the highest burden of early-onset cancer. The age-standardized incidence rate of early-onset cancer increased with the sociodemographic index, and the age-standardized death rate decreased considerably when sociodemographic index increased from 0.7 to 1. The projections indicated that the global age-standardized incidence and death rates of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in friuts, high in sodium and low in milk, etc.), alcohol consumption, and tobacco use are the main risk factors underlying early-onset cancers. CONCLUSIONS Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex, and cancer types, which could burden countries' health systems. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.",

author = "Jianhui Zhao and Liying Xu and Jing Sun and Mingyang Song and Lijuan Wang and Shuai Yuan and Yingshuang Zhu and Zhengwei Wan and Larsson, {Susanna C.} and Tsilidis, {Konstantinos K} and Dunlop, {Malcolm G} and Harry Campbell and Igor Rudan and Peige Song and Evropi Theodoratou and Kefeng Ding and Xue Li",

year = "2023",

month = sep,

day = "5",

doi = "10.1136/bmjonc-2023-000049",

language = "English",

volume = "2",

journal = "BMJ Oncology",

issn = "2752-7948",

publisher = "BMJ Publishing Group Ltd",

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TY - JOUR

T1 - The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019

AU - Zhao, Jianhui

AU - Xu, Liying

AU - Sun, Jing

AU - Song, Mingyang

AU - Wang, Lijuan

AU - Yuan, Shuai

AU - Zhu, Yingshuang

AU - Wan, Zhengwei

AU - Larsson, Susanna C.

AU - Tsilidis, Konstantinos K

AU - Dunlop, Malcolm G

AU - Campbell, Harry

AU - Rudan, Igor

AU - Song, Peige

AU - Theodoratou, Evropi

AU - Ding, Kefeng

AU - Li, Xue

PY - 2023/9/5

Y1 - 2023/9/5

N2 - OBJECTIVE This study aimed to explore the global burden of early-onset cancer (<50 years) based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwide.DESIGN A survey for global burden of early-onset cancer from 1990 to 2019.DATA SOURCE The GBD database in 2019 based on a total of 1250 censuses and 747 location-years of population registry data worldwide. Individuals with early-onset cancer between 1990 and 2019 from GBD database 2019. MAIN OUTCOMES AND MEASURES Incidence, deaths, disability-adjusted life-years (DALYs) and risk factors for 29 early-onset cancer groups.RESULTS Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% betwen 1990-2019. Early-onset breast, tracheal, bronchus, and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle sociodemographic index regions had the highest burden of early-onset cancer. The age-standardized incidence rate of early-onset cancer increased with the sociodemographic index, and the age-standardized death rate decreased considerably when sociodemographic index increased from 0.7 to 1. The projections indicated that the global age-standardized incidence and death rates of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in friuts, high in sodium and low in milk, etc.), alcohol consumption, and tobacco use are the main risk factors underlying early-onset cancers. CONCLUSIONS Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex, and cancer types, which could burden countries' health systems. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.

AB - OBJECTIVE This study aimed to explore the global burden of early-onset cancer (<50 years) based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwide.DESIGN A survey for global burden of early-onset cancer from 1990 to 2019.DATA SOURCE The GBD database in 2019 based on a total of 1250 censuses and 747 location-years of population registry data worldwide. Individuals with early-onset cancer between 1990 and 2019 from GBD database 2019. MAIN OUTCOMES AND MEASURES Incidence, deaths, disability-adjusted life-years (DALYs) and risk factors for 29 early-onset cancer groups.RESULTS Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% betwen 1990-2019. Early-onset breast, tracheal, bronchus, and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle sociodemographic index regions had the highest burden of early-onset cancer. The age-standardized incidence rate of early-onset cancer increased with the sociodemographic index, and the age-standardized death rate decreased considerably when sociodemographic index increased from 0.7 to 1. The projections indicated that the global age-standardized incidence and death rates of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in friuts, high in sodium and low in milk, etc.), alcohol consumption, and tobacco use are the main risk factors underlying early-onset cancers. CONCLUSIONS Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex, and cancer types, which could burden countries' health systems. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.

U2 - 10.1136/bmjonc-2023-000049

DO - 10.1136/bmjonc-2023-000049

M3 - Article

SN - 2752-7948

VL - 2

JO - BMJ Oncology

JF - BMJ Oncology

M1 - e000049

ER -

The Global Trends in Incidence, Death, Burden and Risk Factors of Early-onset Cancer From 1990 to 2019

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Colorectal cancer reduction through risk stratification of screening, follow-up and treatment

Cite this