The GUDMAP database - an online resource for genitourinary research

Simon D. Harding*, Chris Armit, Jane Armstrong, Jane Brennan, Ying Cheng, Bernard Haggarty, Derek Houghton, Sue Lloyd-MacGilp, Xingjun Pi, Yogmatee Roochun, Mehran Sharghi, Christopher Tindal, Andrew P. McMahon, Brian Gottesman, Melissa H. Little, Kylie Georgas, Bruce J. Aronow, S. Steven Potter, Eric W. Brunskill, E. Michelle Southard-SmithCathy Mendelsohn, Richard A. Baldock, Jamie A. Davies, Duncan Davidson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an international consortium working to generate gene expression data and transgenic mice. GUDMAP includes data from large-scale in situ hybridisation screens (wholemount and section) and microarray gene expression data of microdissected, laser-captured and FACS-sorted components of the developing mouse genitourinary (GU) system. These expression data are annotated using a high-resolution anatomy ontology specific to the developing murine GU system. GUDMAP data are freely accessible at www.gudmap.org via easy-to-use interfaces. This curated, high-resolution dataset serves as a powerful resource for biologists, clinicians and bioinformaticians interested in the developing urogenital system. This paper gives examples of how the data have been used to address problems in developmental biology and provides a primer for those wishing to use the database in their own research.

Original languageEnglish
Pages (from-to)2845-2853
Number of pages9
JournalDevelopment
Volume138
Issue number13
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • EMBRYO
  • In situ hybridisation
  • GENE-EXPRESSION ANALYSIS
  • Database
  • ARCHIVE
  • NEPHRON
  • PATTERNS
  • Gene expression
  • RESOLUTION
  • UPDATE
  • Microarray
  • MOUSE KIDNEY
  • REVEALS
  • Genitourinary
  • DEVELOPING KIDNEY

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