The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): Rationale, design, and baseline characteristics

Richard Lowrie, Frances S Mair, Nicola Greenlaw, Paul Forsyth, Alex McConnachie, Janice Richardson, Nina Khan, Deborah Morrison, Claudia-Martina Messow, Brian Rae, John J.V. McMurray

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Aims
The effect on mortality and morbidity of pharmacist-led intervention to optimize pharmacological therapy in patients with systolic heart failure (HF) has not been tested in a large-scale, long-term, clinical trial.

Methods
We describe the rationale and design of a UK, primary care-based, prospective cluster-randomized controlled trial of a pharmacist-led intervention in HF and report baseline characteristics of the patients randomized. Eighty-seven practices (1092 patients) were assigned to the intervention arm and 87 practices (1077 patients) to usual care. The average age of patients at baseline was 71 years, 70% were male, 86% were treated with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and 62% with a beta-blocker. Data for the primary outcome of death from any cause or hospitalization for HF will be available up to 31 December 2010, giving a mean follow-up of 5 years. More than 750 patients would have experienced the primary outcome during this period. The first secondary outcome is death from any cause or hospitalization for a cardiovascular reason. Deaths and hospitalizations are being identified using the Scottish National Health Service electronic patient record-linkage system (hence the delay between the end of follow-up and database lock).

Conclusion
This trial is powered to provide a robust evaluation of the effect of pharmacist-led treatment optimization in patients with systolic HF in primary care.
Original languageEnglish
Pages (from-to)917-924
Number of pages9
JournalEuropean Journal of Heart Failure
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2011

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