The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation

Tina Schmidt, Hannah Striebinger, Juergen Haas, Susanne M. Bailer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an evolutionarily conserved protein with roles in signal transduction and gene expression. An impact of hnRNP K on the life cycle of a broad range of viral pathogens was reported while functional data for herpesviruses were lacking. In this study we show that hnRNP K is important for Herpes simplex virus 1 egress. In absence of hnRNP K, viral entry, gene expression, viral DNA replication, and maturation of nuclear particles appear normal whereas release of infectious virions to the extracellular space was significantly affected. Our results indicate that hnRNP K has an impact on a late step of herpesviral propagation making it a potential antiviral target. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)4361-4365
Number of pages5
JournalFEBS Letters
Volume584
Issue number20
DOIs
Publication statusPublished - 22 Oct 2010

Keywords / Materials (for Non-textual outputs)

  • Comparative Study
  • Computational Biology
  • Contig Mapping
  • genes
  • genetics
  • Genome
  • Genome,Human
  • Genomics
  • human
  • methods
  • Public Sector
  • Publishing
  • SEQUENCE

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